ArticleCerebral cortex (New York, N.Y. : 1991)2014
Medial entorhinal grid cells and head direction cells rotate with a T-maze more often during less recently experienced rotations.
Article in Cerebral cortex (New York, N.Y. : 1991), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed.
- Coordinating Cognition: The Entorhinal Cortex in Mnemonic, Temporal and Spatial Representation.Cells · 2026Review
- Gated transformations from egocentric to allocentric reference frames involving retrosplenial cortex, entorhinal cortex, and hippocampus.Hippocampus · 2023Review
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- Article
- Grid-Cell Activity on Linear Tracks Indicates Purely Translational Remapping of 2D Firing Patterns at Movement Turning Points.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
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- Head direction is coded more strongly than movement direction in a population of entorhinal neurons.Brain research · 2015Article
- Retrosplenial cortex maps the conjunction of internal and external spaces.Nature neuroscience · 2015Article
- A high-resolution study of hippocampal and medial temporal lobe correlates of spatial context and prospective overlapping route memory.Hippocampus · 2014Article
- The vestibular contribution to the head direction signal and navigation.Frontiers in integrative neuroscience · 2014Review
- Modeling of grid cell activity demonstrates in vivo entorhinal 'look-ahead' properties.Neuroscience · 2013Article
- Neurophysiological coding of space and time in the hippocampus, entorhinal cortex, and retrosplenial cortex.Brain and neuroscience advancesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Prior studies of head direction (HD) cells indicate strong landmark control over the preferred firing direction of these cells, with few studies exhibiting shifts away from local reference frames over time. We recorded spiking activity of grid and HD cells in the medial entorhinal cortex of rats, testing correlations of local environmental cues with the spatial tuning curves of these cells' firing fields as animals performed continuous spatial alternation on a T-maze that shared the boundaries of an open-field arena. The environment was rotated into configurations the animal had either seen or not seen in the past recording week. Tuning curves of both cell types demonstrated commensurate shifts of tuning with T-maze rotations during less recent rotations, more so than recent rotations. This strongly suggests that animals are shifting their reference frame away from the local environmental cues over time, learning to use a different reference frame more likely reliant on distal or idiothetic cues. In addition, grid fields demonstrated varying levels of "fragmentation" on the T-maze. The propensity for fragmentation does not depend on grid spacing and grid score, nor animal trajectory, indicating the cognitive treatment of environmental subcompartments is likely driven by task demands.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.