ReviewEpidemiologic reviews2013
Biochemical markers of aging for longitudinal studies in humans.
Review in Epidemiologic reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Perceived Age as a Mortality and Comorbidity Predictor: A Systematic Review.Aesthetic plastic surgery · 2023Pooled it
- Erasable serum markers.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- An Expert Consensus Statement on Biomarkers of Aging for Use in Intervention Studies.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Effects of brisk walking with or without music on body composition, standing balance, cardiovascular parameters, and salivary biomarkers in older women.Journal of exercise rehabilitation · 2024Article
- A novel approach to quantifying individual's biological aging using Korea's national health screening program toward precision public health.GeroScience · 2024Article
- Review
- Predicting mortality risk after a fall in older adults using health care spending patterns: a population-based cohort study.Age and ageing · 2023Article
- Article
- Serum Copper-to-Zinc Ratio and Risk of Chronic Obstructive Pulmonary Disease: A Cohort Study.Lung · 2023Article
- Machine learning models of healthcare expenditures predicting mortality: A cohort study of spousal bereaved Danish individuals.PloS one · 2023Article
- Biological Age Predictors: The Status Quo and Future Trends.International journal of molecular sciences · 2022Review
- Serum copper-to-zinc ratio and risk of incident pneumonia in caucasian men: a prospective cohort study.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2022Article
- Do changes in frailty, physical functioning, and cognitive functioning predict mortality in old age? Results from the Longitudinal Aging Study Amsterdam.BMC geriatrics · 2022Article
- Longitudinal telomere length and body composition in healthy term-born infants during the first two years of life.PloS one · 2021Article
- Ranking Biomarkers of Aging by Citation Profiling and Effort Scoring.Frontiers in genetics · 2021Review
- Article
- Anti-Inflammatory and Anti-Aging Evaluation of Pigment-Protein Complex Extracted fromMarine drugs · 2019Article
- Hallmarks of senescence and aging.Biochemia medica · 2019Review
- Accelerating research on biological aging and mental health: Current challenges and future directions.Psychoneuroendocrinology · 2019Review
- Chronic Obstructive Pulmonary Disease as a Main Factor of Premature Aging.International journal of environmental research and public health · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Much progress has been made in the past decades in unraveling the mechanisms that are responsible for aging. The discovery that particular gene mutations in experimental species such as yeast, flies, and nematodes are associated with longevity has led to many important insights into pathways that regulate aging processes. However, extrapolating laboratory findings in experimental species to knowledge that is valid for the complexity of human physiology remains a major challenge. Apart from the restricted experimental possibilities, studying aging in humans is further complicated by the development of various age-related diseases. The availability of a set of biomarkers that really reflect underlying aging processes would be of much value in disentangling age-associated pathology from specific aging mechanisms. In this review, we survey the literature to identify promising biochemical markers of aging, with a particular focus on using them in longitudinal studies of aging in humans that entail repeated measurements on easily obtainable material, such as blood samples. Our search strategy was a 2-pronged approach, one focused on general mechanisms of aging and one including studies on clinical biomarkers of age-related diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.