ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2013
Clinicopathologic findings predictive of relapse in children with stage III favorable-histology Wilms tumor.
Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 98 citations in OpenAlex.
- A Scoping Review on Fluorescence-Guided Surgery in Paediatric Renal Tumours: Current Perspectives and Future Plans.Cancers · 2026Review
- Analysis of prognostic factors and development of a predictive model following radical nephrectomy for Wilms tumor in children.Oncology letters · 2025Article
- Updated favourable-histology Wilms tumour risk stratification: rationale for future Children's Oncology Group clinical trials.Nature reviews. Urology · 2025Review
- Prediction values of different lymph nodes staging systems for survival of children with Wilms tumor.Translational cancer research · 2024Article
- Insights into Personalized Care Strategies for Wilms Tumor: A Narrative Literature Review.Biomedicines · 2024Review
- Prognostic role of primary tumor size in Wilms tumor.Oncology letters · 2024Article
- Article
- Review
- Extended Lymph Node Sampling During Surgery for Pediatric Renal Tumors Concerning for Malignancy Does Not Increase Postoperative Complication Rates.The Journal of urology · 2023Article
- Multidisciplinary Treatment Strategies for Wilms Tumor: Recent Advances, Technical Innovations and Future Directions.Frontiers in pediatrics · 2022Review
- Impact of the First Generation of Children's Oncology Group Clinical Trials on Clinical Practice for Wilms Tumor.Journal of the National Comprehensive Cancer Network : JNCCN · 2021Review
- Review
- A long non-coding RNAs expression signature to improve prognostic prediction of Wilms tumor in children.Translational pediatrics · 2021Article
- Identification of CDC20 as a Novel Biomarker in Diagnosis and Treatment of Wilms Tumor.Frontiers in pediatrics · 2021Article
- Impact of local control and surgical lymph node evaluation in localized paratesticular rhabdomyosarcoma: A report from the Children's Oncology Group Soft Tissue Sarcoma Committee.International journal of cancer · 2020Article
- Localized Wilms' tumor in low-middle-income countries (LMIC): how can we get better?Journal of the Egyptian National Cancer Institute · 2020Article
- Relapsed Wilms' tumor in pediatric patients: challenges in low- to middle-income countries-a single-center experience.Journal of the Egyptian National Cancer Institute · 2020Article
- Factors affecting lymph node sampling patterns and the impact on survival of lymph node density in patients with Wilms tumor: a Surveillance, Epidemiology, and End Result (SEER) database review.Journal of pediatric urology · 2020Article
- How many lymph nodes are enough? Assessing the adequacy of lymph node yield for staging in favorable histology wilms tumor.Journal of pediatric surgery · 2019Article
- Imaging of Wilms tumor: an update.Pediatric radiology · 2019Review
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
purposeStage III designation in NWTS-5 (National Wilms Tumor Study-5) was determined by four pathologic criteria: positive lymph nodes (LNs), peritoneal implants, residual disease, and tumor rupture. The objective of this study was to determine the prognostic significance of each of the stage III criteria. PATIENTS AND
methodsChildren with stage III Wilms tumor (WT) treated in NWTS-5 were assessed for event-free (EFS) and overall survival (OS). Sites of relapse and molecular status of tumors are reported. EFS and OS are reported 8 years after diagnosis.
resultsThere were 569 patients with local stage III favorable-histology (FH) WT in this analysis, of whom 109 had overall stage IV disease. LN involvement alone was the most frequent criterion for stage III designation (38%), followed by microscopic residual disease alone (20%), microscopic residual disease and LN involvement (14%), and spill or soilage alone (9%). The 8-year EFS and OS estimates for all patients with local stage III FHWT were 82% and 91%, respectively. Multivariate analysis demonstrated that both LN involvement (relative risk, 1.89; P = .005) and microscopic residual disease (relative risk, 1.87; P = .007) were predictive of EFS, and OS results were similar. There was no apparent difference in pattern of relapse according to stage III subtype. The rate of loss of heterozygosity was higher (6%) for those with positive LNs than for those without (2%; P = .05).
conclusionLN involvement and microscopic residual are the stage III criteria highly predictive of EFS and OS for patients with stage III FHWT. It is possible that in future studies, patients with different stage III criteria may receive different therapies.
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