ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2013
Observing micro-evolutionary processes of viral populations at multiple scales.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Silent reservoir species are shaping the emergence of Usutu virus.Nature ecology & evolution · 2026Article
- Cross-scale dynamics and the evolutionary emergence of infectious diseases.Virus evolution · 2021Article
- Estimating viral bottleneck sizes for FMDV transmission within and between hosts and implications for the rate of viral evolution.Interface focus · 2020Article
- Article
- Investigating intra-host and intra-herd sequence diversity of foot-and-mouth disease virus.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2016Article
- Can You Judge a Disease Host by the Company It Keeps? Predicting Disease Hosts and Their Relative Importance: A Case Study for Leishmaniasis.PLoS neglected tropical diseases · 2016Article
- Transmission or Within-Host Dynamics Driving Pulses of Zoonotic Viruses in Reservoir-Host Populations.PLoS neglected tropical diseases · 2016Review
- Within-host dynamics of infection: from ecological insights to evolutionary predictions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- The impact of within-herd genetic variation upon inferred transmission trees for foot-and-mouth disease virus.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2015Article
- Distinguishing low frequency mutations from RT-PCR and sequence errors in viral deep sequencing data.BMC genomics · 2015Article
- Article
- Next-generation sequencing in veterinary medicine: how can the massive amount of information arising from high-throughput technologies improve diagnosis, control, and management of infectious diseases?Methods in molecular biology (Clifton, N.J.) · 2015Review
- Changes in diversification patterns and signatures of selection during the evolution of murinae-associated hantaviruses.Viruses · 2014Article
- Multiple introductions of serotype O foot-and-mouth disease viruses into East Asia in 2010-2011.Veterinary research · 2013Article
- Evolutionary epidemiology: preparing for an age of genomic plenty.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Article
- Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Advances in sequencing technology coupled with new integrative approaches to data analysis provide a potentially transformative opportunity to use pathogen genome data to advance our understanding of transmission. However, to maximize the insights such genetic data can provide, we need to understand more about how the microevolution of pathogens is observed at different scales of biological organization. Here, we examine the evolutionary processes in foot-and-mouth disease virus observed at different scales, ranging from the tissue, animal, herd and region. At each scale, we observe analogous processes of population expansion, mutation and selection resulting in the accumulation of mutations over increasing time scales. While the current data are limited, rates of nucleotide substitution appear to be faster over individual-to-individual transmission events compared with those observed at a within-individual scale suggesting that viral population bottlenecks between individuals facilitate the fixation of polymorphisms. Longer-term rates of nucleotide substitution were found to be equivalent in individual-to-individual transmission compared with herd-to-herd transmission indicating that viral diversification at the herd level is not retained at a regional scale.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.