ArticleInternational journal of epidemiology2013
Leukocyte telomere length and the father's age enigma: implications for population health and for life course.
Article in International journal of epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 71 citations in OpenAlex.
- Trial
- Exposure to metal mixtures and telomere length in Bangladeshi children.American journal of epidemiology · 2025Article
- Chromosome ends and the theory of marginotomy: implications for reproduction.Biogerontology · 2024Review
- Sub-optimal maternal gestational gain is associated with shorter leukocyte telomere length at birth in a predominantly Latinx cohort of newborns.Maternal health, neonatology and perinatology · 2023Article
- Impact of Advanced Paternal Age on Fertility and Risks of Genetic Disorders in Offspring.Genes · 2023Review
- Advanced Paternal Age and Future Generations.Frontiers in endocrinology · 2022Review
- Urinary arsenic and relative telomere length in 5-7 year old children in Bangladesh.Environment international · 2021Article
- Telomere length: how the length makes a difference.Molecular biology reports · 2020Review
- In utero exposure to endocrine-disrupting chemicals and telomere length at birth.Environmental research · 2020Article
- Parental age and offspring leukocyte telomere length and attrition in midlife: Evidence from the 1946 British birth cohort.Experimental gerontology · 2018Article
- Healthy pregnancy and prevention of psychosis.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2018Article
- Article
- Telomere length and early trauma in schizophrenia.Schizophrenia research · 2018Article
- Heritability of telomere variation: it is all about the environment!Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Usefulness of telomere length in DNA from human teeth for age estimation.International journal of legal medicine · 2018Article
- No evidence for parental age effects on offspring leukocyte telomere length in free-living Soay sheep.Scientific reports · 2017Article
- Leukocyte Telomere Length in Newborns: Implications for the Role of Telomeres in Human Disease.Pediatrics · 2016Article
- The paradox of longer sperm telomeres in older men's testes: a birth-cohort effect caused by transgenerational telomere erosion in the female germline.Molecular cytogenetics · 2016Article
- On being the right size: increased body size is associated with reduced telomere length under natural conditions.Proceedings. Biological sciences · 2015Article
- Telomere shortening in Down syndrome patients--when does it start?DNA and cell biology · 2015Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
What are the implications for population health of the demographic trend toward increasing paternal age at conception (PAC) in modern societies? We propose that the effects of older PAC are likely to be broad and harmful in some domains of health but beneficial in others. Harmful effects of older PAC have received the most attention. Thus, for example, older PAC is associated with an increased risk of offspring having rare conditions such as achondroplasia and Marfan syndrome, as well as with neurodevelopmental disorders such as autism. However, newly emerging evidence in the telomere field suggests potentially beneficial effects, since older PAC is associated with a longer leukocyte telomere length (LTL) in offspring, and a longer LTL is associated with a reduced risk of atherosclerosis and with increased survival in the elderly. Thus, older PAC may cumulatively increase resistance to atherosclerosis and lengthen lifespan in successive generations of modern humans. In this paper we: (i) introduce these novel findings; (ii) discuss potential explanations for the effect of older PAC on offspring LTL; (iii) draw implications for population health and for life course; (iv) put forth an evolutionary perspective as a context for the multigenerational effects of PAC; and (v) call for broad and intensive research to understand the mechanisms underlying the effects of PAC. We draw together work across a range of disciplines to offer an integrated perspective of this issue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.