ArticleILAR journal2012
Neoplasia and neoplasm-associated lesions in laboratory colonies of zebrafish emphasizing key influences of diet and aquaculture system design.
Article in ILAR journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed.
- INHAND: Non-proliferative and proliferative lesions of fish - Chapter 4. Fish endocrine system.Journal of toxicologic pathology · 2026Article
- INHAND: Non-proliferative and proliferative lesions of fish - Chapter 2. Fish cardiovascular system.Journal of toxicologic pathology · 2026Article
- INHAND: Non-proliferative and proliferative lesions of fish - Chapter 9. Fish female reproductive system.Journal of toxicologic pathology · 2026Article
- INHAND: Non-proliferative and proliferative lesions of fish - Chapter 14. Fish special senses.Journal of toxicologic pathology · 2026Article
- INHAND: Non-proliferative and proliferative lesions of fish - Chapter 13. Fish soft tissues.Journal of toxicologic pathology · 2026Article
- INHAND: Non-proliferative and proliferative lesions of fish - Chapter 8. Fish nervous system.Journal of toxicologic pathology · 2026Article
- INHAND: Non-proliferative and proliferative lesions of fish - Chapter 3. Fish digestive system.Journal of toxicologic pathology · 2026Article
- INHAND: Non-proliferative and proliferative lesions of fish - Chapter 5. Fish hematolymphoid system.Journal of toxicologic pathology · 2026Article
- INHAND: Non-proliferative and proliferative lesions of fish - Chapter 12. Fish skeletal and tooth.Journal of toxicologic pathology · 2026Article
- cGAS-STING are responsible for premature aging of telomerase-deficient zebrafish.The EMBO journal · 2025Article
- Thyroid C-Cell Biology and Oncogenic Transformation.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2025Review
- Review
- Thyroid neoplasia associated with nutritional deficiency in cultured jade perch in Hong Kong.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2024Article
- Review of neoplasia in fish at a large display aquarium, 2005-2021.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2024Article
- Zebrafish ambra1b knockout reveals a novel role for Ambra1 in primordial germ cells survival, sex differentiation and reproduction.Biological research · 2023Article
- FELASA-AALAS Recommendations for Monitoring and Reporting of Laboratory Fish Diseases and Health Status, with an Emphasis on Zebrafish (Comparative medicine · 2022Article
- Gonadal Abnormality and Intersexuality of Oplegnathus fasciatus (Teleostei: Oplegnathidae) Collected from the Southern Coast of Korea: A Case Report.Development & reproduction · 2021Article
- Review
- Current basis and future directions of zebrafish nutrigenomics.Genes & nutrition · 2019Review
- Folic acid-nanoscale gadolinium-porphyrin metal-organic frameworks: fluorescence and magnetic resonance dual-modality imaging and photodynamic therapy in hepatocellular carcinoma.International journal of nanomedicine · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
During the past decade, the zebrafish has emerged as a leading model for mechanistic cancer research because of its sophisticated genetic and genomic resources, its tractability for tissue targeting of transgene expression, its efficiency for forward genetic approaches to cancer model development, and its cost effectiveness for enhancer and suppressor screens once a cancer model is established. However, in contrast with other laboratory animal species widely used as cancer models, much basic cancer biology information is lacking in zebrafish. As yet, data are not published regarding dietary influences on neoplasm incidences in zebrafish. Little information is available regarding spontaneous tumor incidences or histologic types in wild-type lines of zebrafish. So far, a comprehensive database documenting the full spectrum of neoplasia in various organ systems and tissues is not available for zebrafish as it is for other intensely studied laboratory animal species. This article confirms that, as in other species, diet and husbandry can profoundly influence tumor incidences and histologic spectra in zebrafish. We show that in many laboratory colonies wild-type lines of zebrafish exhibit elevated neoplasm incidences and neoplasm-associated lesions such as heptocyte megalocytosis. We present experimental evidence showing that certain diet and water management regimens can result in high incidences of neoplasia and neoplasm-associated lesions. We document the wide array of benign and malignant neoplasms affecting nearly every organ, tissue, and cell type in zebrafish, in some cases as a spontaneous aging change, and in other cases due to carcinogen treatment or genetic manipulation.
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