ArticleProceedings of the National Academy of Sciences of the United States of America2013
Rice zinc finger protein DST enhances grain production through controlling Gn1a/OsCKX2 expression.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers, 1 of them a synthesis that pooled it.
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Who cites it
138 citing papers in PubMed, 1 synthesis or guideline pooled it, 315 citations in OpenAlex.
- A Meta-Analysis of Comparative Transcriptomic Data Reveals a Set of Key Genes Involved in the Tolerance to Abiotic Stresses in Rice.International journal of molecular sciences · 2019Pooled it
- Candidate genes identification for internode length in rice via genome-wide association studies.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- WLG coordinates multi-stress tolerance in rice by regulating DST-dependent HNature communications · 2026Article
- High-Throughput Phenotyping: Status and Applications in Rice Breeding.Plants (Basel, Switzerland) · 2026Review
- Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- The DTH8-SD1 pair regulates panicle architecture in rice.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- "Bud to bloom"-hormonal coordination in floral initiation.Plant biology (Stuttgart, Germany) · 2025Review
- The C2H2 Zinc-Finger protein ELR1 negatively regulates cytokinin metabolism and signaling pathway in rice.Functional & integrative genomics · 2025Article
- Grain shape in rice: a Genome-wide association study of the effector genes.BMC plant biology · 2025Article
- Genome-wide analysis of the L-type lectin-like receptor kinase (LecRLK) gene family in upland cotton and verification of the response of GhLecRLK90 to drought stress.Functional & integrative genomics · 2025Article
- Rice Transcription Factor HSTL Regulates Plant Height and Salt Stress Response by Modulating Gibberellin Homeostasis.Rice (New York, N.Y.) · 2025Article
- Allelic value in gene regulation-implications for gene editing.Annals of botany · 2025Article
- Enhanced rice breeding with GLR1_CAPS marker for glabrous hull selection.BMC plant biology · 2025Article
- A Novel OsMPK6-OsMADS47-PPKL1/3 Module Controls Grain Shape and Yield in Rice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Rice grain size: current regulatory mechanisms and future perspectives.Journal of plant research · 2025Review
- FZP modulates tillering via OsMADS57 in rice.Plant biotechnology journal · 2025Article
- Competitive binding of small antagonistic peptides to the OsER1 receptor optimizes rice panicle architecture.Plant communications · 2025Article
- Genome scans capture key adaptation and historical hybridization signatures in tetraploid wheat.The plant genome · 2025Article
- Gene Pyramiding Strategies for Sink Size and Source Capacity for High-Yield Japonica Rice Breeding.Rice (New York, N.Y.) · 2025Review
- Surviving floods: Escape and quiescence strategies of rice coping with submergence.Plant physiology · 2025Article
78 more citing papers are in PubMed but not listed here.
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Authors and funding
15 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The phytohormone cytokinin (CK) positively regulates the activity and function of the shoot apical meristem (SAM), which is a major parameter determining seed production. The rice (Oryza sativa L.) Gn1a/OsCKX2 (Grain number 1a/Cytokinin oxidase 2) gene, which encodes a cytokinin oxidase, has been identified as a major quantitative trait locus contributing to grain number improvement in rice breeding practice. However, the molecular mechanism of how the expression of OsCKX2 is regulated in planta remains elusive. Here, we report that the zinc finger transcription factor DROUGHT AND SALT TOLERANCE (DST) directly regulates OsCKX2 expression in the reproductive meristem. DST-directed expression of OsCKX2 regulates CK accumulation in the SAM and, therefore, controls the number of the reproductive organs. We identify that DST(reg1), a semidominant allele of the DST gene, perturbs DST-directed regulation of OsCKX2 expression and elevates CK levels in the reproductive SAM, leading to increased meristem activity, enhanced panicle branching, and a consequent increase of grain number. Importantly, the DST(reg1) allele provides an approach to pyramid the Gn1a-dependent and Gn1a-independent effects on grain production. Our study reveals that, as a unique regulator of reproductive meristem activity, DST may be explored to facilitate the genetic enhancement of grain production in rice and other small grain cereals.
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