ArticleProceedings of the National Academy of Sciences of the United States of America2013
Male-specific lethal complex in Drosophila counteracts histone acetylation and does not mediate dosage compensation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed, 59 citations in OpenAlex.
- Vertebrate and Invertebrate Animal Models for the Study of Down Syndrome.International journal of molecular sciences · 2025Review
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- Calcium Homeostasis Is Involved in the Modulation of Gene Expression by MSL2 in Imbalanced Genomes.Cells · 2024Article
- Inverse and ProportionalGenes · 2024Article
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- Genome-Wide Expression Analysis of Long Noncoding RNAs and Their Target Genes in MetafemaleInternational journal of molecular sciences · 2023Article
- Modulation of Global Gene Expression by Aneuploidy and CNV of Dosage Sensitive Regulatory Genes.Genes · 2021Article
- Interaction of Male Specific Lethal complex and genomic imbalance on global gene expression in Drosophila.Scientific reports · 2021Article
- Rapid Evolution of Autosomal Binding Sites of the Dosage Compensation Complex inFrontiers in genetics · 2021Article
- Multilayered Tuning of Dosage Compensation and Z-Chromosome Masculinization in the Wood White (Leptidea sinapis) Butterfly.Genome biology and evolution · 2019Article
- RNA-on-X 1 and 2 in Drosophila melanogaster fulfill separate functions in dosage compensation.PLoS genetics · 2018Article
- Non-canonical Drosophila X chromosome dosage compensation and repressive topologically associated domains.Epigenetics & chromatin · 2018Article
- Dosage-Dependent Expression Variation Suppressed on theG3 (Bethesda, Md.) · 2018Article
- The X-linked 1.688 Satellite inGenetics · 2018Article
- RNA sequencing reveals a complete but an unconventional type of dosage compensation in the domestic silkwormRoyal Society open science · 2017Article
- Male-Killing Spiroplasma Alters Behavior of the Dosage Compensation Complex during Drosophila melanogaster Embryogenesis.Current biology : CB · 2016Article
- Primary Sex Determination in Drosophila melanogaster Does Not Rely on the Male-Specific Lethal Complex.Genetics · 2016Article
- Dosage Compensation in the African Malaria Mosquito Anopheles gambiae.Genome biology and evolution · 2016Article
- Messenger RNA profile analysis deciphers new Esrrb responsive genes in prostate cancer cells.BMC molecular biology · 2015Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Dosage compensation is achieved in male Drosophila by a twofold up-regulation of the single X chromosome to reach the level of the two X chromosomes in females. A popular hypothesis to explain this phenomenon is that the male-specific lethal (MSL) complex, which is present at high levels on the male X, mediates this modulation of gene expression. One member of the complex, MOF, a histone acetyltransferase, acetylates lysine 16 of histone H4 and another, MSL2, which is only expressed in males, triggers its assembly. Here, we find that when a GAL4-MOF fusion protein is targeted to an upstream-activating sequence linked to a miniwhite reporter, up-regulation occurs in females but down-regulation in males, even though in the latter the whole MSL complex is recruited to the reporter genes and produces an increased histone acetylation. The expression of a GAL4-MSL2 fusion protein does not cause dosage compensation of X and autosomal reporters in females, although its expression causes the organization of the MSL complex on the reporter genes, leading to increased histone acetylation. RNAseq analysis of global endogenous gene expression in females with ectopic expression of MSL2 to coat the X chromosomes shows no evidence of increased expression compared with normal females. These data from multiple approaches indicate that the MSL complex does not mediate dosage compensation directly, but rather its activity overrides the high level of histone acetylation and counteracts the potential overexpression of X-linked genes to achieve the proper twofold up-regulation in males.
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