ReviewEnvironmental health and preventive medicine2013
Developmental origins of obesity and type 2 diabetes: molecular aspects and role of chemicals.
Review in Environmental health and preventive medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 98 citations in OpenAlex.
- The Developmental Origins of Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis.American journal of human biology : the official journal of the Human Biology Council · 2025Pooled it
- Relationship between prenatal growth, postnatal growth and childhood obesity: a review.European journal of clinical nutrition · 2017Pooled it
- Trial
- Association of air purifier usage during pregnancy with adverse birth outcomes: the Japan Environment and Children's Study.BMC public health · 2024Article
- Relation Between Obesity and Type 2 Diabetes: Evolutionary Insights, Perspectives and Controversies.Current obesity reports · 2024Review
- Inverse associations of cord blood mitochondrial DNA copy number with childhood adiposity.Obesity (Silver Spring, Md.) · 2024Article
- Fetal and neonatal dioxin exposure causes sex-specific metabolic alterations in mice.Toxicological sciences : an official journal of the Society of Toxicology · 2023Article
- Tris(4-chlorophenyl)methane and tris(4-chlorophenyl)methanol disrupt pancreatic organogenesis and gene expression in zebrafish embryos.Birth defects research · 2023Article
- Nutritional Modulation of Associations between Prenatal Exposure to Persistent Organic Pollutants and Childhood Obesity: A Prospective Cohort Study.Environmental health perspectives · 2023Article
- Season of birth and atopic dermatitis in early infancy: results from the Japan Environment and Children's Study.BMC pediatrics · 2023Article
- Anti-Obesity Effect of Chitoglucan in High-Fat-Induced Obesity Mice.International journal of environmental research and public health · 2022Article
- Evidence for Quercetin as a Dietary Supplement for the Treatment of Cardio-Metabolic Diseases in Pregnancy: A Review in Rodent Models.Foods (Basel, Switzerland) · 2022Review
- Developmental Timing of High-Fat Diet Exposure Impacts Glucose Homeostasis in Mice in a Sex-Specific Manner.Diabetes · 2021Article
- Aerobic exercise training prevents impairment in renal parameters and in body composition of rats fed a high sucrose diet.BMC research notes · 2021Article
- Diabetic Kinome Inhibitors-A New Opportunity for β-Cells Restoration.International journal of molecular sciences · 2021Review
- Maternal preconception PFOS exposure of Drosophila melanogaster alters reproductive capacity, development, morphology and nutrient regulation.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2021Article
- Developmental exposures to perfluorooctanesulfonic acid (PFOS) impact embryonic nutrition, pancreatic morphology, and adiposity in the zebrafish, Danio rerio.Environmental pollution (Barking, Essex : 1987) · 2021Article
- The Role of Leptin in the Development of Energy Homeostatic Systems and the Maintenance of Body Weight.Frontiers in physiology · 2021Review
- Offspring susceptibility to metabolic alterations due to maternal high-fat diet and the impact of inhaled ozone used as a stressor.Scientific reports · 2020Article
- Early overnutrition sensitizes the growth hormone axis to the impact of diet-induced obesity via sex-divergent mechanisms.Scientific reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is a leading risk factor for impaired glucose tolerance and type 2 diabetes (T2D). Although the cause of the obesity epidemic is multi-factorial and not entirely clear, the recent acceleration in incidence is too rapid to be accounted for only by genetics, the wide availability of calorie-rich foods, and increasingly sedentary lifestyles. Accumulating data suggest that the important causes of the obesity epidemic may be related to developmental and early life environmental conditions. The concept of the developmental origins of health and disease (DOHaD) suggests that adverse influences early in development, particularly during intrauterine life, may result in permanent changes in the physiology and metabolism of the infant, which in turn result in an increased risk of non-communicable diseases in adulthood. For example, undernutrition during pregnancy and rapid postnatal weight gain are associated with obesity and T2D in the adult offspring. Moreover, increasing evidence suggests that early-life exposure to a wide range of chemicals has a significant impact on the causes of metabolic disorders. Although the underlying molecular mechanisms remain to be determined, these factors can affect epigenetic processes, such as DNA methylation, allowing the developmental environment to modulate gene transcription. The objective of this review article was to summarize recent progress in the biomedical implications of the DOHaD concept, focusing on the pathogenesis of obesity and T2D, and to discuss a future direction for preventive strategies from a public health perspective.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.