ArticleInfection and immunity2013
5-Lipoxygenase activity increases susceptibility to experimental Paracoccidioides brasiliensis infection.
Article in Infection and immunity, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- Cysteinyl leukotriene receptor-1 as a potential target for host-directed therapy during chronic schistosomiasis in murine model.Frontiers in immunology · 2024Article
- Resolvin D1 Attenuates Innate Immune Reactions in Experimental Subarachnoid Hemorrhage Rat Model.Molecular neurobiology · 2021Article
- Re-drawing the Maps for Endemic Mycoses.Mycopathologia · 2020Review
- The Lipoxin Receptor/FPR2 Agonist BML-111 Protects Mouse Skin Against Ultraviolet B Radiation.Molecules (Basel, Switzerland) · 2020Article
- Regulatory T cells in paracoccidioidomycosis.Virulence · 2019Review
- 43 kDa Glycoprotein (gp43) fromJournal of immunology research · 2019Article
- Lipoxin A4, a 5-lipoxygenase pathway metabolite, modulates immune response during acute respiratory tularemia.Journal of leukocyte biology · 2017Article
- Th17-Inducing Cytokines IL-6 and IL-23 Are Crucial for Granuloma Formation during Experimental Paracoccidioidomycosis.Frontiers in immunology · 2017Article
- Severe Paracoccidioidomycosis in a 14-Year-Old Boy.Mycopathologia · 2016Article
- Lipoxin Signaling in Murine Lung Host Responses to Cryptococcus neoformans Infection.American journal of respiratory cell and molecular biology · 2016Article
- Mammalian lipoxygenases and their biological relevance.Biochimica et biophysica acta · 2015Review
- Nucleosides present on phlebotomine saliva induce immunossuppression and promote the infection establishment.PLoS neglected tropical diseases · 2015Article
- Lipoxin Inhibits Fungal Uptake by Macrophages and Reduces the Severity of Acute Pulmonary Infection Caused by Paracoccidioides brasiliensis.Mediators of inflammation · 2015Article
- Human leucocyte antigen-G (HLA-G) and its murine functional homolog Qa2 in the Trypanosoma cruzi Infection.Mediators of inflammation · 2015Article
- Fatty acids, lipid mediators, and T-cell function.Frontiers in immunology · 2014Review
- Protective role of 5-lipoxigenase during Leishmania infantum infection is associated with Th17 subset.BioMed research international · 2014Article
- The left lung is preferentially targeted during experimental paracoccidioidomycosis in C57BL/6 mice.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2013Article
- The pivotal role of 5-lipoxygenase-derived LTB4 in controlling pulmonary paracoccidioidomycosis.PLoS neglected tropical diseases · 2013Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paracoccidioidomycosis (PCM) is a systemic mycosis caused by the thermodimorphic fungus Paracoccidioides brasiliensis. Leukotrienes and lipoxins are lipid mediators produced after 5-lipoxygenase (5-LO) activation that exhibit pro- and anti-inflammatory roles, respectively. Here, we have investigated the contribution of 5-LO enzymatic activity in PCM using an experimental model of P. brasiliensis infection. B6.129 wild-type (B6.129) and 5-LO-deficient (5-LO(-/-)) mice were intravenously inoculated with a virulent strain of P. brasiliensis (Pb18), and the survival rate of the infected mice was investigated on different days after yeast infection. 5-LO(-/-) mice exhibited an increased survival rate associated with a decreased number of CFU. The resistance of 5-LO(-/-) during PCM was associated with augmented nitric oxide (NO) production and the formation of compact granulomas. In addition, the absence of 5-LO was associated with a diminished number of CD4(+) CD25(+) regulatory T cells, higher levels of gamma interferon and interleukin-12, and increased T-bet (a T-box transcription factor that directs Th1 lineage commitment) mRNA levels in the lungs. Taken together, our results show for the first time that 5-LO enzymatic activity increases susceptibility to P. brasiliensis, suggesting that this pathway may be a potential target for therapeutic intervention during PCM.
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