ArticleThe Journal of physiology2013
Differential responses of fast- and slow-conducting pyramidal tract neurons to changes in accuracy demands during locomotion.
Article in The Journal of physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Activity of cat premotor cortex neurons during visually guided stepping.Journal of neurophysiology · 2023Article
- Signals from posterior parietal area 5 to motor cortex during locomotion.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Neuronal activity reorganization in motor cortex for successful locomotion after a lesion in the ventrolateral thalamus.Journal of neurophysiology · 2022Article
- Contribution of the ventrolateral thalamus to the locomotion-related activity of motor cortex.Journal of neurophysiology · 2020Article
- Gaze coordination with strides during walking in the cat.The Journal of physiology · 2019Article
- The use of transcranial magnetic stimulation to evaluate cortical excitability of lower limb musculature: Challenges and opportunities.Restorative neurology and neuroscience · 2018Review
- Accurate stepping on a narrow path: mechanics, EMG, and motor cortex activity in the cat.Journal of neurophysiology · 2015Article
- Known and unexpected constraints evoke different kinematic, muscle, and motor cortical neuron responses during locomotion.The European journal of neuroscience · 2015Article
- Activity of somatosensory-responsive neurons in high subdivisions of SI cortex during locomotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Impact of treatment duration and lesion size on effectiveness of chondroitinase treatment post-SCI.Experimental neurology · 2015Article
- Body stability and muscle and motor cortex activity during walking with wide stance.Journal of neurophysiology · 2014Article
- EphA4-mediated ipsilateral corticospinal tract misprojections are necessary for bilateral voluntary movements but not bilateral stereotypic locomotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Postnatal maturation of the red nucleus motor map depends on rubrospinal connections with forelimb motor pools.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Most movements need to be accurate. The neuronal mechanisms controlling accuracy during movements are poorly understood. In this study we compare the activity of fast- and slow-conducting pyramidal tract neurons (PTNs) of the motor cortex in cats as they walk over both a flat surface, a task that does not require accurate stepping and can be accomplished without the motor cortex, as well as along a horizontal ladder, a task that requires accuracy and the activity of the motor cortex to be successful. Fast- and slow-conducting PTNs are known to have distinct biophysical properties as well as different afferent and efferent connections. We found that while the activity of all PTNs changes substantially upon transition from simple locomotion to accurate stepping on the ladder, slow-conducting PTNs respond in a much more concerted manner than fast-conducting ones. As a group, slow-conducting PTNs increase discharge rate, especially during the late stance and early swing phases, decrease discharge variability, have a tendency to shift their preferred phase of the discharge into the swing phase, and almost always produce a single peak of activity per stride during ladder locomotion. In contrast, the fast-conducting PTNs do not display such concerted changes to their activity. In addition, upon transfer from simple locomotion to accurate stepping on the ladder slow-conducting PTNs more profoundly increase the magnitude of their stride-related frequency modulation compared with fast-conducting PTNs. We suggest that slow-conducting PTNs are involved in control of accuracy of locomotor movements to a greater degree than fast-conducting PTNs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.