Evidence map›Paper›PMID 23381190›Full record

ReviewNature reviews. Gastroenterology & hepatology2013

Current management strategies and emerging treatments for functional dyspepsia.

Michael Camilleri, Vincenzo Stanghellini

Erratum issued Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Gastroenterology & hepatology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03884270 (Self-Administered Hypnotherapy for Functional Dyspepsia), which is not on this map. Cited by 49 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 6 pooled it
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03884270 nacompletednot on this mapstarted 2019, after this paper: background citation

Self-Administered Hypnotherapy for Functional Dyspepsia

TypeinterventionalSponsorSarah KinsingerRan2019 to 2020Enrolled23ConditionsFunctional DyspepsiaArmsHypnotherapy
3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 6 syntheses or guidelines pooled it, 180 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Pooled it
  4. Proton pump inhibitors for functional dyspepsia.The Cochrane database of systematic reviews · 2017
    Pooled it
  5. Pooled it
  6. Proton pump inhibitors for functional dyspepsia.The Cochrane database of systematic reviews · 2017
    Pooled it
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Article
  13. Article
  14. Weichang' an pill alleviates functional dyspepsia through modulating brain-gut peptides and gut microbiota.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2024
    Article
  15. Article
  16. Article
  17. Potential Value of Biomarker-Based Approaches for Evaluation and Management of Costly Functional Gastrointestinal Diseases.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2023
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Michael CamilleriClinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), Mayo Clinic, 200 First Street S.W., Rochester, MN 55905, USA.
Vincenzo Stanghellini
Mayo Clinic in Florida · USPoliclinico S.Orsola-Malpighi · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Functional dyspepsia refers to painful and nonpainful symptoms that are perceived to arise in the upper digestive tract but are not secondary to organic, systemic or metabolic diseases. The symptoms of this syndrome often overlap with those of GERD and IBS, making its management far from simple. If Helicobacter pylori infection is diagnosed in patients with functional dyspepsia, it should be treated. In patients with mild or intermittent symptoms, reassurance and lifestyle advice might be sufficient; in patients not responding to these measures, or in those with more severe symptoms, drug therapy should be considered. Both PPIs and prokinetics can be used in initial empirical pharmacotherapy based on symptom patterns--a PPI is more likely to be effective in the presence of retrosternal or epigastric burning or epigastric pain, whereas a prokinetic is more effective in dyspepsia with early satiation or postprandial fullness. Although combinations of PPIs and prokinetics might have additive symptomatic effects, single-drug therapy is initially preferable. Antidepressants or referral to a psychiatrist or psychotherapist can be considered in nonresponders and in those whose symptoms have a marked effect on daily functioning. Despite extensive research, functional dyspepsia treatment often remains unsatisfactory. Better characterization of dyspeptic subgroups and understanding of underlying mechanisms will enable treatment advances to be made in the future.

Indexed as

Disease ManagementAntidepressive AgentsDyspepsiaHumansLife StyleProton Pump InhibitorsTreatment OutcomeAntidepressive AgentsProton Pump Inhibitors

Identifiers

PMID23381190
OpenAlexW2031725670

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.