ReviewLab on a chip2013
Microfluidic sample preparation for diagnostic cytopathology.
Review in Lab on a chip, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- Portable Sensing Systems in Biological and Chemical Analyses: A Review of Sensor Technologies, Miniaturized Platforms, Data Processing, and Field Applications.Micromachines · 2026Review
- Ridge-assisted micro positioning of cells in a channel.Science advances · 2026Article
- Circulating Tumor Cells: Emerging Frontiers in Cancer Technology.Expert reviews in molecular medicine · 2026Review
- Ridge-assisted Micro Positioning of Cells and Particles in a Microchannel.bioRxiv : the preprint server for biology · 2025Article
- Assessing the quality of whole slide images in cytology from nuclei features.Journal of pathology informatics · 2025Article
- Surface Acoustic Wave-Enhanced Multi-View Acoustofluidic Rotation Cytometry (MARC) for Pre-Cytopathological Screening.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Influence of the internal structure of straight microchannels on inertial transport behavior of particles.Heliyon · 2024Article
- Investigation of Inlet Conditions in The Mixing Process of Nanoparticles and Blood in a T-Shaped Microfluidic Reactor with Small Rectangular Cavities.The Yale journal of biology and medicine · 2023Article
- Article
- Single-Cell Proteomics: The Critical Role of Nanotechnology.International journal of molecular sciences · 2022Review
- Hand-Powered Inertial Microfluidic Syringe-Tip Centrifuge.Biosensors · 2021Article
- Acoustic Microfluidic Separation Techniques and Bioapplications: A Review.Micromachines · 2020Review
- A Review of Secondary Flow in Inertial Microfluidics.Micromachines · 2020Review
- Label-free microfluidic sorting of microparticles.APL bioengineering · 2019Review
- A Microfluidic Device for Simultaneous Extraction of Plasma, Red Blood Cells, and On-Chip White Blood Cell Trapping.Scientific reports · 2018Article
- Isolation of cells from whole blood using shear-induced diffusion.Scientific reports · 2018Article
- Geometrically enhanced sensor surfaces for the selective capture of cell-like particles in a laminar flow field.Biomicrofluidics · 2018Article
- Computer Aided Diagnosis System for Detection of Cancer Cells on Cytological Pleural Effusion Images.BioMed research international · 2018Article
- Microfluidic cell concentrator with a reduced-deviation-flow herringbone structure.Biomicrofluidics · 2017Article
- Patient-Derived Airway Secretion Dissociation Technique To Isolate and Concentrate Immune Cells Using Closed-Loop Inertial Microfluidics.Analytical chemistry · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The cellular components of body fluids are routinely analyzed to identify disease and treatment approaches. While significant focus has been placed on developing cell analysis technologies, tools to automate the preparation of cellular specimens have been more limited, especially for body fluids beyond blood. Preparation steps include separating, concentrating, and exposing cells to reagents. Sample preparation continues to be routinely performed off-chip by technicians, preventing cell-based point-of-care diagnostics, increasing the cost of tests, and reducing the consistency of the final analysis following multiple manually-performed steps. Here, we review the assortment of biofluids for which suspended cells are analyzed, along with their characteristics and diagnostic value. We present an overview of the conventional sample preparation processes for cytological diagnosis. We finally discuss the challenges and opportunities in developing microfluidic devices for the purpose of automating or miniaturizing these processes, with particular emphases on preparing large or small volume samples, working with samples of high cellularity, automating multi-step processes, and obtaining high purity subpopulations of cells. We hope to convey the importance of and help identify new research directions addressing the vast biological and clinical applications in preparing and analyzing the array of available biological fluids. Successfully addressing the challenges described in this review can lead to inexpensive systems to improve diagnostic accuracy while simultaneously reducing overall systemic healthcare costs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.