Evidence map›Paper›PMID 23380915›Full record

ArticleChemical communications (Cambridge, England)2013

Antimicrobial metallopeptides with broad nuclease and ribonuclease activity.

Jeff C Joyner, W F Hodnick, Ada S Cowan, Deepika Tamuly, Rachel Boyd, J A Cowan

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. DNA Scission by Non-Histidine Amino-Terminal Cu(II) and Ni(II) Binding-Like Peptides.Chembiochem : a European journal of chemical biology · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Amphiphilic Aminoglycosides as Medicinal Agents.International journal of molecular sciences · 2020
    Review
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Target-directed catalytic metallodrugs.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2013
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jeff C JoynerDepartment of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, OH 43210, USA. cowan@chemistry.ohio-state.edu
W F Hodnick
Ada S Cowan
Deepika Tamuly
Rachel Boyd
J A Cowan

Funding

CHEMISTRY/BIOLOGY TRAINING GRANTT32GM008512 · NIGMS · OHIO STATE UNIVERSITY · PI PEI, DEHUA · 1996 to 2016
$3.9M
Novel Catalytic MetalloDrug Targeting IRES RNA for Treatment of HCV InfectionR44AA016712 · NIAAA · METALLOPHARM, LLC · PI COWAN, ADA S · 2011 to 2013
$2.0M
METALLOPEPTIDES AS THERAPEUTIC AGENTSR21HL093446 · NHLBI · OHIO STATE UNIVERSITY · PI COWAN, JAMES A · 2009 to 2010
$408k
Novel Engineered Synthetic Metallodrugs Directed Against HCVR43AA016712 · NIAAA · METALLOPHARM, LLC · PI CHING, SAN · 2007 to 2008
$257k
NHLBI NIH HHS HL093446NHLBI NIH HHS R21 HL093446NIAAA NIH HHS AA016712NIAAA NIH HHS R43 AA016712NIAAA NIH HHS R44 AA016712NIGMS NIH HHS T32 GM008512NIGMS NIH HHS T32 GM08512
6 · The paper itself

Abstract

Metallopeptides containing both the complex Cu(2+)-glycyl-glycyl-histidine (Cu-GGH) and the sequence WRWYCR were shown to possess antimicrobial activity against a variety of pathogenic bacteria, as well as bind to and cleave a variety of nucleic acids, suggesting potential mechanisms for antimicrobial activity that involve binding and/or irreversible cleavage of bacterial nucleic acids.

Indexed as

Amino Acid SequenceAnti-Infective AgentsBacteriaCoordination ComplexesCopperDeoxyribonucleasesDNAMicrobial Sensitivity TestsOligopeptidesPeptidesRibonucleasesRNAAnti-Infective AgentsCoordination ComplexesCopperDeoxyribonucleasesdiglycyl-histidineDNAOligopeptidesPeptidesRibonucleasesRNA

Identifiers

PMID23380915
PMCPMC3632407

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.