Evidence map›Paper›PMID 23380875›Full record

ArticleOncology reports2013

Sleeping Beauty transposon system harboring HRAS, c-Myc and shp53 induces sarcomatoid carcinomas in mouse skin.

Sunyoung Jung, Simon Weonsang Ro, Geunyoung Jung, Hye-Lim Ju, Eun-Sil Yu, Woo-Chan Son

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. [Establishment of New Zealand rabbit models of aplastic anemia].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2017
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Sunyoung JungAsan Institute for Life Sciences, Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
Simon Weonsang Ro
Geunyoung Jung
Hye-Lim Ju
Eun-Sil Yu
Woo-Chan Son
University of Ulsan · KRYonsei University · KRAsan Medical Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Sleeping Beauty transposon system is used as a tool for insertional mutagenesis and oncogenesis. However, little is known about the exact histological phenotype of the tumors induced. Thus, we used immunohistochemical markers to enable histological identification of the type of tumor induced by subcutaneous injection of the HRAS, c-Myc and shp53 oncogenes in female C57BL/6 mice. The tumor was removed when it reached 100 mm3 in volume. Subsequently, we used 13 immunohistochemical markers to histologically identify the tumor type. The results suggested that the morphology of the tumor was similar to that of sarcomatoid carcinoma.

Indexed as

AnimalsCarcinomaCell Transformation, NeoplasticDNA Transposable ElementsFemaleGene Expression Regulation, NeoplasticHumansInjections, SubcutaneousMiceMice, Inbred C57BLMutagenesis, InsertionalPositron-Emission TomographyProto-Oncogene Proteins c-mycProto-Oncogene Proteins p21(ras)RadiographyRNA, Small InterferingDNA Transposable ElementsHRAS protein, humanMYC protein, humanProto-Oncogene Proteins c-mycProto-Oncogene Proteins p21(ras)RNA, Small Interferingsleeping beauty transposase, humanTransposasesTumor Suppressor Protein p53

Identifiers

PMID23380875
PMCPMC3621733
OpenAlexW2094570441

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.