ReviewIEEE transactions on bio-medical engineering2013
Neuromodulation for brain disorders: challenges and opportunities.
Review in IEEE transactions on bio-medical engineering, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02950506 (Transcranial Direct Current Stimulation and Cognitive Remediation Therapy for Interictal Dysfunction in Epilepsy), which is not on this map. Cited by 115 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Transcranial Direct Current Stimulation and Cognitive Remediation Therapy for Interictal Dysfunction in Epilepsy
Who cites it
115 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Bilateral Cingulotomy as a Therapeutic Option for Intractable Cancer Pain: a Systematic Review.Current pain and headache reports · 2025Pooled it
- Critical review of the evidence for Vojta Therapy: a systematic review and meta-analysis.Frontiers in neurology · 2024Pooled it
- A meta-analysis on the therapeutic efficacy of repetitive transcranial magnetic stimulation for cognitive functions in attention-deficit/hyperactivity disorders.BMC psychiatry · 2023Pooled it
- Novel Extranasal Tear Stimulation: Pivotal Study Results.Translational vision science & technology · 2020Trial
- Interventional Treatment of Arterial Hypertension in The Modern Era: An Updated Review from the Young Investigator Group of the European Society of Hypertension.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026Review
- Review
- Efficacy of non-invasive neuromodulation for chronic tinnitus: a systematic review and meta-analysis of randomized controlled trials.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Review
- Neuromodulation in Neuro-Oncology: A Scoping Review.Journal of personalized medicine · 2026Review
- Neurovascular Uncoupling in Alzheimer's and Parkinson's Diseases: Mechanisms and Therapeutic Strategies.Brain sciences · 2026Review
- Low-intensity transcranial focused ultrasound engages parvalbumin-positive GABAergic interneurons in a humanized mouse model of chronic pain: from electrophysiology to cellular investigation.Journal of neural engineering · 2026Article
- Spinal Cord Stimulation Improves Deceleration Phase Control during Targeted Reaching Post-Stroke.Research square · 2026Article
- PEDOT:PSS-A Key Material for Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Effect of repetitive transcranial magnetic stimulation modulating supplementary motor area in stroke rehabilitation: Systematic review of randomized controlled trials.AIMS neuroscience · 2026Review
- Spinal Cord Stimulation Improves Feedback Control of Reaching Post-Stroke.medRxiv : the preprint server for health sciences · 2025Article
- Brain‑heart axis: Neurostimulation techniques in ischemic heart disease (Review).International journal of molecular medicine · 2025Review
- Artificial Intelligence-Driven Neuromodulation in Neurodegenerative Disease: Precision in Chaos, Learning in Loss.Biomedicines · 2025Review
- γ neuromodulations: unraveling biomarkers for neurological and psychiatric disorders.Military Medical Research · 2025Review
- Insular Cortex Modulation by Repetitive Transcranial Magnetic Stimulation with Concurrent Functional Magnetic Resonance Imaging: Preliminary Findings.Brain sciences · 2025Article
- Neuromodulation techniques in traumatic brain injury: a narrative review of the current state.Acta neurologica Belgica · 2025Review
- Temporal interference stimulation over the motor cortex enhances cortical excitability in rats.Scientific reports · 2025Article
55 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
The field of neuromodulation encompasses a wide spectrum of interventional technologies that modify pathological activity within the nervous system to achieve a therapeutic effect. Therapies including deep brain stimulation, intracranial cortical stimulation, transcranial direct current stimulation, and transcranial magnetic stimulation have all shown promising results across a range of neurological and neuropsychiatric disorders. While the mechanisms of therapeutic action are invariably different among these approaches, there are several fundamental neuroengineering challenges that are commonly applicable to improving neuromodulation efficacy. This paper reviews the state-of-the-art of neuromodulation for brain disorders and discusses the challenges and opportunities available for clinicians and researchers interested in advancing neuromodulation therapies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.