Evidence map›Paper›PMID 23380700›Full record

ArticleInternational journal of cardiology2013

Prevention of heart failure in older adults may require higher levels of physical activity than needed for other cardiovascular events.

Kanan Patel, Xuemei Sui, Yan Zhang, Gregg C Fonarow, Inmaculada B Aban, Cynthia J Brown, Vera Bittner, Dalane W Kitzman, Richard M Allman, Maciej Banach and 4 more

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in International journal of cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
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  11. Increased cardiovascular stiffness and impaired age-related functional status.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 3 countries.

Kanan PatelUniversity of Alabama at Birmingham, Birmingham, AL, USA.
Xuemei Sui
Yan Zhang
Gregg C Fonarow
Inmaculada B Aban
Cynthia J Brown
Vera Bittner
Dalane W Kitzman
Richard M Allman
Maciej Banach
Wilbert S Aronow
Stefan D Anker
Steven N Blair
Ali Ahmed
University of Alabama at Birmingham · USBirmingham VA Medical Center · USUniversity of South Carolina · USIstituti di Ricovero e Cura a Carattere Scientifico · ITMedical University of Lodz · PLNew York Medical College · USUniversity of California, Los Angeles · USWake Forest University · US

Funding

UAB CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE (CCTS) UL1: BPCAUL1RR025777 · NCRR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUAY-WOODFORD, LISA MARIE · 2008 to 2011
$22.3M
Exercise Intolerance in Older HFPEF PatientsR01AG018915 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI KITZMAN, DALANE W · 2001 to 2019
$5.2M
NCRR NIH HHS 5UL1 RR025777NCRR NIH HHS UL1 RR025777NIA NIH HHS R01 AG018915
6 · The paper itself

Abstract

backgroundLittle is known if the levels of physical activity required for the prevention of incident heart failure (HF) and other cardiovascular events vary in community-dwelling older adults.

methodsWe studied 5503 Cardiovascular Health Study (CHS) participants, age ≥ 65 years, free of baseline HF. Weekly metabolic equivalent task-minutes (MET-minutes), estimated using baseline total leisure-time energy expenditure, were used to categorize participants into four physical activity groups: inactive (0 MET-minutes; n=489; reference), low (1-499; n=1458), medium (500-999; n=1086) and high (≥ 1000; n=2470).

resultsParticipants had a mean (± SD) age of 73 (± 6) years, 58% were women, and 15% African American. During 13 years of follow-up, centrally-adjudicated incident HF occurred in 26%, 23%, 20%, and 19% of participants with no, low, medium and high physical activity, respectively (trend p<0.001). Compared with inactive older adults, age-sex-race-adjusted hazard ratios (95% confidence intervals) for incident HF associated with low, medium and high physical activity were 0.87 (0.71-1.06; p=0.170), 0.68 (0.54-0.85; p=0.001) and 0.60 (0.49-0.74; p<0.001), respectively (trend p<0.001). Only high physical activity had significant independent association with lower risk of incident HF (HR, 0.79; 95% CI, 0.64-0.97; p=0.026). All levels of physical activity had significant independent association with lower risk of incident acute myocardial infarction (AMI), stroke and cardiovascular mortality.

conclusionIn community-dwelling older adults, high level of physical activity was associated with lower risk of incident HF, but all levels of physical activity were associated with lower risk of incident AMI, stroke, and cardiovascular mortality.

Indexed as

AgedConfidence IntervalsExerciseExercise TherapyFemaleFollow-Up StudiesHeart FailureHumansIncidenceMaleMotor ActivityPrognosisProspective StudiesRisk AssessmentSurvival RateUnited StatesIncident heart failureMET-minutesOlder adultsPhysical activity

Identifiers

PMID23380700
PMCPMC4142221
OpenAlexW2045038958

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.