ArticleCancer biology & therapy2013
Ocimum gratissimum retards breast cancer growth and progression and is a natural inhibitor of matrix metalloproteases.
Article in Cancer biology & therapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Ethnobotany, Phytochemistry, and Pharmacological Activities ofInternational journal of molecular sciences · 2026Pooled it
- Exploring the Multifaceted Health Benefits of Natural Dietary Sources: Antimicrobial, Antioxidant, Anticancer, and Antidiabetic Properties.Recent patents on biotechnology · 2026Review
- Effect of Light Intensity and Light Spectrum of LED Light Sources on Photosynthesis and Secondary Metabolite Synthesis inPlants (Basel, Switzerland) · 2025Article
- Fractionated Leaf Extracts ofNutrients · 2024Article
- In Vitro and In Vivo Anticancer Activity of Basil (Cancers · 2022Review
- Polyphenol-rich extract of Ocimum gratissimum leaves prevented toxic effects of cyclophosphamide on the kidney function of Wistar rats.BMC complementary medicine and therapies · 2021Article
- A review on the traditional uses, phytochemistry, and pharmacological activities of clove basil (Heliyon · 2021Review
- Protective Effects ofInternational journal of medical sciences · 2021Article
- Integration of medicinal plants into the traditional system of medicine for the treatment of cancer in Sokoto State, Nigeria.Heliyon · 2020Article
- AqueousInternational journal of medical sciences · 2020Article
- Article
- Ocimum basilicum but not Ocimum gratissimum present cytotoxic effects on human breast cancer cell line MCF-7, inducing apoptosis and triggering mTOR/Akt/p70S6K pathway.Journal of bioenergetics and biomembranes · 2018Article
- Amelioration of estrogen-deficiency-induced obesity byInternational journal of medical sciences · 2017Article
- Omega-3 fatty acid is a potential preventive agent for recurrent colon cancer.Cancer prevention research (Philadelphia, Pa.) · 2014Article
- Galectin-3 in angiogenesis and metastasis.Glycobiology · 2014Review
- Heparanase cooperates with Ras to drive breast and skin tumorigenesis.Cancer research · 2014Article
- Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Ocimum genus (a.k.a holy basil or tulsi) is a dietary herb used for its multiple beneficial pharmacologic properties including anti-cancer activity. Here we show that crude extract of Ocimum gratissimum (OG) and its hydrophobic and hydrophilic fractions (HB and HL) differentially inhibit breast cancer cell chemotaxis and chemoinvasion in vitro and retard tumor growth and temporal progression of MCF10ADCIS.com xenografts, a model of human breast comedo-ductal carcinoma in situ (comedo-DCIS). OG-induced inhibition of tumor growth was associated with decreases in basement membrane disintegration, angiogenesis and MMP-2 and MMP-9 activities as confirmed by in situ gelatin zymography and cleavage of galectin-3. There was also decrease in MMP-2 and MMP-9 activities in the conditioned media of OG-treated MCF10AT1 and MCF10AT1-EIII8 premalignant human breast cancer cells as compared with control. The MMP-2 and MMP-9 inhibitory activities of OG were verified in vitro using gelatin, a synthetic fluorogenic peptide and recombinant galectin-3 as MMP substrates. Mice fed on OG-supplemented drinking water showed no adverse effects compared with control. These data suggest that OG is non-toxic and that the anti-cancer therapeutic activity of OG may in part be contributed by its MMP inhibitory activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.