ArticleHormones and behavior2013
Sex-dependent role of the amygdala in the development of emotional and neuroendocrine reactivity to threatening stimuli in infant and juvenile rhesus monkeys.
Article in Hormones and behavior, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- The nature of individual differences in inhibited temperament and risk for psychiatric disease: A review and meta-analysis.Progress in neurobiology · 2015Pooled it
- Nonhuman Primate Models to Explore Mechanisms Underlying Early-Life Temperamental Anxiety.Biological psychiatry · 2021Review
- Emotional responses in monkeys differ depending on the stimulus type, sex, and neonatal amygdala lesion status.Behavioral neuroscience · 2020Article
- Bridging the species gap in translational research for neurodevelopmental disorders.Neurobiology of learning and memory · 2019Article
- Early amygdala damage alters the way rhesus macaques process species-specific audio-visual vocalizations.Behavioral neuroscience · 2019Article
- Postnatal Zika virus infection is associated with persistent abnormalities in brain structure, function, and behavior in infant macaques.Science translational medicine · 2018Article
- Persistent alteration in behavioural reactivity to a mild social stressor in rhesus monkeys repeatedly exposed to sevoflurane in infancy.British journal of anaesthesia · 2018Article
- Advances in nonhuman primate models of autism: Integrating neuroscience and behavior.Experimental neurology · 2018Review
- Neonatal perirhinal cortex lesions impair monkeys' ability to modulate their emotional responses.Behavioral neuroscience · 2017Article
- The developing amygdala: a student of the world and a teacher of the cortex.Current opinion in psychology · 2017Review
- The effects of neonatal amygdala or hippocampus lesions on adult social behavior.Behavioural brain research · 2017Article
- Maternal buffering beyond glucocorticoids: impact of early life stress on corticolimbic circuits that control infant responses to novelty.Social neuroscience · 2017Article
- MRI Overestimates Excitotoxic Amygdala Lesion Damage in Rhesus Monkeys.Frontiers in integrative neuroscience · 2017Article
- Increased irritability, anxiety, and immune reactivity in transgenic Huntington's disease monkeys.Brain, behavior, and immunity · 2016Article
- Implications of newborn amygdala connectivity for fear and cognitive development at 6-months-of-age.Developmental cognitive neuroscience · 2016Article
- Multiple Anesthetic Exposure in Infant Monkeys Alters Emotional Reactivity to an Acute Stressor.Anesthesiology · 2015Article
- Adult social behavior with familiar partners following neonatal amygdala or hippocampus damage.Behavioral neuroscience · 2015Article
- Social buffering of stress responses in nonhuman primates: Maternal regulation of the development of emotional regulatory brain circuits.Social neuroscience · 2015Review
- Exploring the Structure of Human Defensive Responses from Judgments of Threat Scenarios.PloS one · 2015Article
- Neonatal amygdala lesions advance pubertal timing in female rhesus macaques.Psychoneuroendocrinology · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Amygdala dysfunction and abnormal fear and stress reactivity are common features of several developmental neuropsychiatric disorders. Yet, little is known about the exact role the amygdala plays in the development of threat detection and emotional modulation. The current study examined the effects of neonatal amygdala lesions on defensive, emotional, and neuroendocrine reactivity of infant rhesus monkeys reared with their mothers in large species-typical social groups. Monkeys received either bilateral MRI-guided ibotenic acid amygdala (Neo-A; n = 16) or sham (Neo-C; n = 12) lesions at 24.8 ± 1.2 days of age, or served as behavioral control (Neo-BC; n = 3). Defensive and emotional responses were assessed using the Human Intruder paradigm as infants and as juveniles (2.5 and 12 months of age, respectively), whereas neuroendocrine reactivity was only examined during the juvenile period. As infants, Neo-A animals expressed similar levels of freezing and hostile behaviors as compared to controls, whereas during the juvenile period Neo-A animals expressed significantly less freezing compared to controls. Interestingly, the sex of the infant modulated the behavioral effects of neonatal amygdalectomy, leading to different patterns of behavior depending on the sex and lesion status of the infant. Unlike controls, Neo-A infants did not modulate their behavioral responses based on the salience of the threat. The impact of neonatal amygdalectomy increased with age, such that Neo-A juveniles exhibited fewer emotional behaviors and increased cortisol response to the stressor as compared to controls. These data indicate that the amygdala plays a critical role in the development of both emotional and neuroendocrine reactivity as well as the expression of sexually dimorphic emotional expression.
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