ArticleBMC medicine2013
Multigenerational epigenetic effects of nicotine on lung function.
Article in BMC medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 68 citations in OpenAlex.
- Smartphone-based financial incentives to promote smoking cessation during pregnancy: A pilot study.Preventive medicine · 2020Trial
- Paternal snus use in puberty and increased risk for asthma and allergies in offspring: a RHINE/RHINESSA two-generation study.International journal of epidemiology · 2026Article
- Epigenetic Alterations Induced by Smoking and Their Intersection with Artificial Intelligence: A Narrative Review.International journal of environmental research and public health · 2025Review
- Pathological epigenetic events and reversibility review: the intersection between hallmarks of aging and developmental origin of health and disease.Epigenomics · 2023Review
- Nicotine on the developing brain.Pharmacological research · 2023Review
- Unprotected Youth Workers in US Agriculture.Frontiers in public health · 2023Article
- Genes, environment, and developmental timing: New insights from translational approaches to understand early origins of respiratory diseases.Pediatric pulmonology · 2021Article
- Effect of Grandmaternal Smoking on Body Size and Proportions at Birth.International journal of environmental research and public health · 2021Article
- Environmental exposures, stem cells, and cancer.Pharmacology & therapeutics · 2019Review
- Voucher-Based Contingency Management is Efficacious but Underutilized in Treating Addictions.Perspectives on behavior science · 2019Article
- Impact of Electronic Cigarette Aerosols on Pregnancy and Early Development.Current opinion in toxicology · 2019Article
- Patterns of Single and Multiple Tobacco Product Use Among US Women of Reproductive Age.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2018Article
- Tobacco and nicotine delivery product use in a national sample of pregnant women.Preventive medicine · 2017Article
- Impact of gestational nicotine exposure on intrauterine and fetal infection in a rodent model.Biology of reproduction · 2017Article
- Plausible Roles for RAGE in Conditions Exacerbated by Direct and Indirect (Secondhand) Smoke Exposure.International journal of molecular sciences · 2017Review
- Emerging concepts in smooth muscle contributions to airway structure and function: implications for health and disease.American journal of physiology. Lung cellular and molecular physiology · 2016Review
- Perinatal nicotine exposure induces myogenic differentiation, but not epithelial-mesenchymal transition in rat offspring lung.Pediatric pulmonology · 2016Article
- 5-Hydroxymethylcytosine-mediated alteration of transposon activity associated with the exposure to adverse in utero environments in human.Human molecular genetics · 2016Article
- The organelle of differentiation in embryos: the cell state splitter.Theoretical biology & medical modelling · 2016Review
- Consumption of Substances of Abuse during Pregnancy Increases Consumption in Offspring: Possible Underlying Mechanisms.Frontiers in nutrition · 2016Review
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A recent preclinical study has shown that not only maternal smoking but also grandmaternal smoking is associated with elevated pediatric asthma risk. Using a well-established rat model of in utero nicotine exposure, Rehan et al. have now demonstrated multigenerational effects of nicotine that could explain this 'grandmother effect'. F1 offspring of nicotine-treated pregnant rats exhibited asthma-like changes to lung function and associated epigenetic changes to DNA and histones in both lungs and gonads. These alterations were blocked by co-administration of the peroxisome proliferator-activated receptor-γ agonist, rosiglitazone, implicating downregulation of this receptor in the nicotine effects. F2 offspring of F1 mated animals exhibited similar changes in lung function to that of their parents, even though they had never been exposed to nicotine. Thus epigenetic mechanisms appear to underlie the multigenerational transmission of a nicotine-induced asthma-like phenotype. These findings emphasize the need for more effective smoking cessation strategies during pregnancy, and cast further doubt on the safety of using nicotine replacement therapy to reduce tobacco use in pregnant women.Please see related article: http://www.biomedcentral.com/1741-7015/10/129.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.