ArticleACS nano2013
Nuclease-resistant DNA via high-density packing in polymeric micellar nanoparticle coronas.
Article in ACS nano, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Design strategies for programmable oligonucleotide nanotherapeutics.Drug discovery today · 2020Pooled it
- Polymeric Nanoparticles for Drug Delivery.Chemical reviews · 2024Review
- Aptamer-based self-assembled nanomicelle enables efficient and targeted drug delivery.Journal of nanobiotechnology · 2023Article
- Two-Dimensional Supramolecular Polymerization of DNA Amphiphiles is Driven by Sequence-Dependent DNA-Chromophore Interactions.Angewandte Chemie (International ed. in English) · 2023Article
- Stimuli Induced Uptake of Protein-Like Peptide Brush Polymers.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- ssDNA nanotubes for selective targeting of glioblastoma and delivery of doxorubicin for enhanced survival.Science advances · 2021Article
- Viral Mimicry as a Design Template for Nucleic Acid Nanocarriers.Frontiers in chemistry · 2021Review
- Hydrophobic Interaction: A Promising Driving Force for the Biomedical Applications of Nucleic Acids.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- Poly(peptide): Synthesis, Structure, and Function of Peptide-Polymer Amphiphiles and Protein-like Polymers.Accounts of chemical research · 2020Article
- Expanding the materials space of DNA via organic-phase ring-opening metathesis polymerization.Chem · 2019Article
- Self-Transfecting Micellar RNA: Modulating Nanoparticle Cell Interactions via High Density Display of Small Molecule Ligands on Micelle Coronas.Bioconjugate chemistry · 2018Article
- Modulating the Cellular Immune Response of Oligonucleotides by Brush Polymer-Assisted Compaction.Small (Weinheim an der Bergstrasse, Germany) · 2017Article
- Enzyme-Targeted Nanoparticles for Delivery to Ischemic Skeletal Muscle.Polymer chemistry · 2017Article
- DNA Island Formation on Binary Block Copolymer Vesicles.Journal of the American Chemical Society · 2016Article
- Biosynthetic Polymers as Functional Materials.Macromolecules · 2016Review
- Biodegradable DNA-Brush Block Copolymer Spherical Nucleic Acids Enable Transfection Agent-Free Intracellular Gene Regulation.Small (Weinheim an der Bergstrasse, Germany) · 2015Article
- Dye Encapsulation in Polynorbornene Micelles.Langmuir : the ACS journal of surfaces and colloids · 2015Article
- Crowding-induced cooperativity in DNA surface hybridization.Scientific reports · 2015Article
- Biocompatible infinite-coordination-polymer nanoparticle-nucleic-acid conjugates for antisense gene regulation.Angewandte Chemie (International ed. in English) · 2015Article
- Mild two-step method to construct DNA-conjugated silicon nanoparticles: scaffolds for the detection of microRNA-21.Bioconjugate chemistry · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Herein, we describe a polymeric micellar nanoparticle capable of rendering nucleic acids resistant to nuclease digestion. This approach relies on utilizing DNA as the polar headgroup of a DNA-polymer amphiphile in order to assemble well-defined, discrete nanoparticles. Dense packing of DNA in the micelle corona allows for hybridization of complementary oligonucleotides while prohibiting enzymatic degradation. We demonstrate the preparation, purification, and characterization of the nanoparticles, then describe their resistance to treatment with endo- and exonucleases including snake-venom phosphodiesterase (SVP), a common, general DNA digestion enzyme.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.