Evidence map›Paper›PMID 23379553›Full record

ArticlePsychological methods2013

Mediation analysis allowing for exposure-mediator interactions and causal interpretation: theoretical assumptions and implementation with SAS and SPSS macros.

Linda Valeri, Tyler J Vanderweele

Erratum issued 2 registry-linked trialsAbstract read
In one paragraph

Article in Psychological methods, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 1,094 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,094citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05723653 narecruitingnot on this mapstarted 2023, after this paper: background citation

Harnessing Social Network Support to Improve Retention in Care and Viral Suppression Among People Living With HIV in Chicago and Alabama: A Hybrid Type I Effectiveness-implementation Trial

TypeinterventionalSponsorUniversity of ChicagoRan2023 to 2027Enrolled900ConditionsHIV SeropositivityArmsSocial Network Support Intervention
NCT06991673 naenrolling by invitationnot on this mapstarted 2025, after this paper: background citation

Adolescent Surgery Roadmap Feasibility and Acceptability Study

TypeinterventionalSponsorUniversity of MichiganRan2025 to 2029Enrolled100ConditionsPediatric Surgical ProceduresArmsBehavioral Treatment
3 · Its place in the literature

Who cites it

1,094 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  11. Testing autonomous motivation as a mechanism of anticipated regret intervention techniques for seasonal flu vaccination.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025
    Trial
  12. Observational
  13. Article
  14. Article
  15. Article
  16. Potential Outcomes Effects in Mediation Designs with Three Experimental Conditions.Prevention science : the official journal of the Society for Prevention Research · 2026
    Article
  17. Article
  18. Review
  19. Article
  20. Article

1,034 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

2 authors.

Linda ValeriDepartment of Biostatistics, School of Public Health, Harvard University, MA 20115, USA. lvaleri@hsph.harvard.edu
Tyler J Vanderweele

Funding

Theory and methods for sufficient cause interactionsR01ES017876 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI VANDERWEELE, TYLER · 2010 to 2014
$1.2M
Bounds for direct and indirect effects with application to perinatal epidemiologyR03HD060696 · NICHD · HARVARD SCHOOL OF PUBLIC HEALTH · PI VANDERWEELE, TYLER · 2010 to 2011
$169k
Theory and methods for interactionR56ES017876 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI TCHETGEN TCHETGEN, ERIC JOEL, VANDERWEELE, TYLER · 2016 to 2016
$150k
NICHD NIH HHS HD060696NIEHS NIH HHS ES017876NIEHS NIH HHS R01 ES017876
6 · The paper itself

Abstract

Mediation analysis is a useful and widely employed approach to studies in the field of psychology and in the social and biomedical sciences. The contributions of this article are several-fold. First we seek to bring the developments in mediation analysis for nonlinear models within the counterfactual framework to the psychology audience in an accessible format and compare the sorts of inferences about mediation that are possible in the presence of exposure-mediator interaction when using a counterfactual versus the standard statistical approach. Second, the work by VanderWeele and Vansteelandt (2009, 2010) is extended here to allow for dichotomous mediators and count outcomes. Third, we provide SAS and SPSS macros to implement all of these mediation analysis techniques automatically, and we compare the types of inferences about mediation that are allowed by a variety of software macros.

Indexed as

CausalityData Interpretation, StatisticalNonlinear DynamicsConfounding Factors, EpidemiologicHumansPsychologyRegression AnalysisResearch DesignSoftwareUser-Computer Interface

Identifiers

PMID23379553
PMCPMC3659198

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.