Trial reportHealth psychology : official journal of the Division of Health Psychology, American Psychological Association2014
Differential sensitivity to prevention programming: a dopaminergic polymorphism-enhanced prevention effect on protective parenting and adolescent substance use.
Trial report in Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.
- A systematic review of gene-by-intervention studies of alcohol and other substance use.Development and psychopathology · 2021Pooled it
- The Family Check-up Intervention Moderates Polygenic Influences on Long-Term Alcohol Outcomes: Results from a Randomized Intervention Trial.Prevention science : the official journal of the Society for Prevention Research · 2019Trial
- Oxytocin Receptor Gene Variant Interacts with Intervention Delivery Format in Predicting Intervention Outcomes for Youth with Conduct Problems.Prevention science : the official journal of the Society for Prevention Research · 2018Trial
- Glucocorticoid Receptor (NR3C1) Gene Polymorphism Moderate Intervention Effects on the Developmental Trajectory of African-American Adolescent Alcohol Abuse.Prevention science : the official journal of the Society for Prevention Research · 2018Trial
- Variation in the oxytocin receptor gene moderates the protective effects of a family-based prevention program on telomere length.Brain and behavior · 2016Trial
- Skin-deep Resilience and Early Adolescence: Neighborhood Disadvantage, Executive Functioning, and Pubertal Development in Minority Youth.Journal of youth and adolescence · 2024Article
- A person-centered data analytic approach to dopaminergic polygenic moderation of child maltreatment exposure.Developmental psychobiology · 2023Article
- Race and genetics versus 'race' in genetics: A systematic review of the use of African ancestry in genetic studies.Evolution, medicine, and public health · 2021Review
- Neural Underpinnings of Social Contextual Influences on Adolescent Risk-Taking.Current addiction reports · 2020Article
- Preventive Effect Heterogeneity: Causal Inference in Personalized Prevention.Prevention science : the official journal of the Society for Prevention Research · 2019Article
- Gene × Environment Interaction in Developmental Disorders: Where Do We Stand and What's Next?Frontiers in psychology · 2018Article
- PROSPER Intervention Effects on Adolescents' Alcohol Misuse Vary by GABRA2 Genotype and Age.Prevention science : the official journal of the Society for Prevention Research · 2018Article
- Commentary for Special Issue of Prevention Science "Using Genetics in Prevention: Science Fiction or Science Fact?"Prevention science : the official journal of the Society for Prevention Research · 2018Article
- Neuroplasticity of selective attention: Research foundations and preliminary evidence for a gene by intervention interaction.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Exploring genetic moderators and epigenetic mediators of contextual and family effects: From Gene × Environment to epigenetics.Development and psychopathology · 2016Review
- Genetic moderation of transactional relations between parenting practices and child self-regulation.Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43) · 2016Article
- Parent and youth dopamine D4 receptor genotypes moderate multilevel contextual effects on rural African American youth's risk behavior.Development and psychopathology · 2016Article
- Application of environmental sensitivity theories in personalized prevention for youth substance abuse: a transdisciplinary translational perspective.Translational behavioral medicine · 2016Review
- Differential susceptibility to environmental influences: Interactions between child temperament and parenting in adolescent alcohol use.Development and psychopathology · 2016Article
- A differential susceptibility analysis reveals the "who and how" about adolescents' responses to preventive interventions: tests of first- and second-generation Gene × Intervention hypotheses.Development and psychopathology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveThe purpose of this study was to investigate a genetic moderation effect of dopamine receptor-4 gene (DRD4) alleles that have 7 or more repeats on the efficacy of a preventive intervention to deter rural African American adolescents' substance use.
methodsAdolescents (N = 502, M age = 16 years) were assigned randomly to the Strong African American Families-Teen (SAAF-T) program or to a control condition and were followed for 22 months. Adolescents provided data on substance use, and both adolescents and their primary caregivers provided data on intervention-targeted protective parenting practices.
resultsMale adolescents who carried at least one allele of DRD4 with 7 or more repeats who were assigned to the control condition evinced more substance use across 22 months than did (a) carriers of at least one allele of DRD4 with 7 or more repeats who were assigned to SAAF-T or (b) adolescents assigned to either condition who carried two alleles of DRD4 with 6 or fewer repeats. These findings were mediated by DRD4 × SAAF-T interaction effects on increases in intervention-targeted protective parenting practices, a mediated moderation effect.
conclusionsThe results imply that prevention effects on health-relevant outcomes for genetically susceptible individuals, such as carriers of at least one allele of DRD4 with 7 or more repeats, may be underestimated.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.