ArticleScientific reports2013
Circulating human basophils lack the features of professional antigen presenting cells.
Article in Scientific reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed.
- Basophils in atopic dermatitis: Immunologic roles and clinical implications.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026Review
- Ticked Off: Allergic Effector Cells in the Pathogenesis of Alpha-gal Syndrome.Current allergy and asthma reports · 2025Review
- IL-33 and IL-3 synergistically induce CD25 expression on human basophils without functional IL-2 signaling: a potential marker of severe COVID-19.Frontiers in immunology · 2025Article
- From the bench to the clinic: basophils and type 2 epithelial cytokines of thymic stromal lymphopoietin and IL-33.Clinical & translational immunology · 2024Review
- Cancer stem cell-immune cell crosstalk in breast tumor microenvironment: a determinant of therapeutic facet.Frontiers in immunology · 2023Review
- Basophils control T cell priming through soluble mediators rather than antigen presentation.Frontiers in immunology · 2022Review
- SARS-CoV-2 Induces Cytokine Responses in Human Basophils.Frontiers in immunology · 2022Article
- Der p 1-based immunotoxin as potential tool for the treatment of dust mite respiratory allergy.Scientific reports · 2020Article
- Is there a Role of Intravenous Immunoglobulin in Immunologic Recurrent Pregnancy Loss?Journal of immunology research · 2020Review
- Adjustments of γδ T Cells in the Lung ofFrontiers in immunology · 2020Article
- Rapid Turnover and High Production Rate of Myeloid Cells in Adult Rhesus Macaques with Compensations during Aging.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- TNature reviews. Immunology · 2018Review
- Demystification of enigma on antigen-presenting cell features of human basophils: data from secondary lymphoid organs.Haematologica · 2017Article
- Granulocytes: New Members of the Antigen-Presenting Cell Family.Frontiers in immunology · 2017Review
- Basophil Activation-Dependent Autoantibody and Interleukin-17 Production Exacerbate Systemic Lupus Erythematosus.Frontiers in immunology · 2017Article
- Myeloid Cells in Asthma.Microbiology spectrum · 2017Review
- Roles of basophils and mast cells in cutaneous inflammation.Seminars in immunopathology · 2016Review
- Commentary: The Expression of CD123 Can Decrease with Basophil Activation: Implications for the Gating Strategy of the Basophil Activation Test.Frontiers in immunology · 2016Article
- Autoimmunity: Basophils in autoimmune and inflammatory diseases.Nature reviews. Rheumatology · 2015Article
- Contribution of Basophils to Cutaneous Immune Reactions and Th2-Mediated Allergic Responses.Frontiers in immunology · 2015Review
Corrections and comments
- Erratum issuedMaddur, Mohan S [added]
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent reports in mice demonstrate that basophils function as antigen presenting cells (APC). They express MHC class II and co-stimulatory molecules CD80 and CD86, capture and present soluble antigens or IgE-antigen complexes and polarize Th2 responses. Therefore, we explored whether human circulating basophils possess the features of professional APC. We found that unlike dendritic cells (DC) and monocytes, steady-state circulating human basophils did not express HLA-DR and co-stimulatory molecules CD80 and CD86. Basophils remained negative for these molecules following stimulation with soluble Asp f 1, one of the allergens of Aspergillus fumigatus; Bet v 1, the major birch allergen; TLR2-ligand or even upon IgE cross-linking. Unlike DC, Asp f 1-pulsed basophils did not promote Th2 responses as analyzed by the secretion of IL-4 in the basophil-CD4(+) T cell co-culture. Together, these results demonstrate the inability of circulating human basophils to function as professional APC.
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