ArticleJournal of developmental origins of health and disease2011
Sex-specific impact of maternal-fetal risk factors on depression and cardiovascular risk 40 years later.
Article in Journal of developmental origins of health and disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed.
- Maternal immune activation by toll-like receptor 7 agonist during mid-gestation increases susceptibility to blood-brain barrier leakage after puberty.Brain behavior and immunity integrative · 2024Article
- Impacts of Maternal Preeclampsia Exposure on Offspring Neuronal Development: Recent Insights and Interventional Approaches.International journal of molecular sciences · 2024Review
- Sex Differences in Hemoglobin A1c Levels Related to the Comorbidity of Obesity and Depression.Journal of women's health (2002) · 2021Article
- Impact of prenatal maternal cytokine exposure on sex differences in brain circuitry regulating stress in offspring 45 years later.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Altered offspring neurodevelopment in an arginine vasopressin preeclampsia model.Translational psychiatry · 2021Article
- Gestational Cytokines and the Developmental Expression of Obesity in Childhood.Obesity (Silver Spring, Md.) · 2020Article
- Maternal Immune activity during pregnancy and socioeconomic disparities in children's self-regulation.Brain, behavior, and immunity · 2020Article
- Impact of sex and depressed mood on the central regulation of cardiac autonomic function.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Neurodevelopmental Outcomes of Prenatal Preeclampsia Exposure.Trends in neurosciences · 2020Review
- The association between depressive mood and ischemic heart disease: a twin study.Acta psychiatrica Scandinavica · 2019Article
- Sex differences in the hypothalamic-pituitary-adrenal axis' response to stress: an important role for gonadal hormones.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- Sex differences in major depression and comorbidity of cardiometabolic disorders: impact of prenatal stress and immune exposures.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
- Sex Differences in the Prenatal Programming of Adult Metabolic Syndrome by Maternal Androgens.The Journal of clinical endocrinology and metabolism · 2018Article
- Depressive Symptoms and Complications Early after Acute Myocardial Infarction: Gender Differences.The open nursing journal · 2018Article
- Corticolimbic regulation of cardiovascular responses to stress.Physiology & behavior · 2017Review
- Prenatal stress-immune programming of sex differences in comorbidity of depression and obesity/metabolic syndrome.Dialogues in clinical neuroscience · 2016Review
- Prenatal immune programming of the sex-dependent risk for major depression.Translational psychiatry · 2016Article
- Socioeconomic disadvantage and neural development from infancy through early childhood.International journal of epidemiology · 2015Article
- Fetal hormonal programming of sex differences in depression: linking women's mental health with sex differences in the brain across the lifespan.Frontiers in neuroscience · 2014Article
- Disruption of fetal hormonal programming (prenatal stress) implicates shared risk for sex differences in depression and cardiovascular disease.Frontiers in neuroendocrinology · 2014Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Major depressive disorder (MDD) and cardiovascular disease (CVD) represent leading causes of morbidity and mortality worldwide. We tested the hypothesis that growth restriction and preeclampsia (referred to as fetal risk) are significant predictors of these conditions, with women at higher risk in adulthood. Adult offspring exposed to fetal risk factors and their discordant siblings were from two prenatal cohorts, whose mothers were followed through pregnancy and whom we recruited as adults 40 years later (n = 538; 250 males and 288 females). Subjects were psychiatrically diagnosed and underwent a stress challenge during which parasympathetic regulation was assessed by electrocardiogram, operationalized as high-frequency R-R interval variability (HF-RRV). Linear mixed models and generalized estimating equations were used to examine the relationship of fetal risk on HF-RRV, MDD and comorbidity of low HF-RRV (lowest 25th percentile) and MDD, including interactions with sex and socioeconomic status (SES). Fetal risk was significantly associated with low HF-RRV response (F = 3.64, P = 0.05), particularly among low SES (interaction: F = 4.31, P < 0.04). When stratified by MDD, the fetal risk impact was three times greater among MDD compared with non-MDD subjects (effect size: 0.21 v. 0.06). Females had a significantly higher risk for the comorbidity of MDD and low HF-RRV than males (relative risk (RR) = 1.36, 95% CI: 1.07-1.73), an association only seen among those exposed to fetal risk (RR = 1.38, 95% CI: 1.04-1.83). Findings suggest that these are shared fetal antecedents to the comorbidity of MDD and CVD risk 40 years later, an association stronger in females than in males.
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Registered trials
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