ReviewFrontiers in neural circuits2013
Circadian clocks, rhythmic synaptic plasticity and the sleep-wake cycle in zebrafish.
Review in Frontiers in neural circuits, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
45 citing papers in PubMed, 89 citations in OpenAlex.
- Impacts of Long-Term High-Temperature and Low-Salinity Stress on the Circadian Rhythms of Antioxidant, Immune, and Endocrine Systems in Turbot (Antioxidants (Basel, Switzerland) · 2026Article
- Lighting and circadian cues shape locomotor strategies for balance and navigation in larval zebrafish.bioRxiv : the preprint server for biology · 2025Article
- Sleep Aid Effect and Mechanism of Semen Zizyphi Spinosae Extract Enriched With Jujuboside and Jujubogenin in Sleep-Deprived Zebrafish.Food science & nutrition · 2025Article
- Modelling orexinergic system in ageing in the African turquoise killifish.Biogerontology · 2025Review
- The Role and Mechanisms of the Hypocretin System in Zebrafish (International journal of molecular sciences · 2024Review
- Analysis of the underlying mechanism ofPharmaceutical science advances · 2024Article
- In vivo photocontrol of orexin receptors with a nanomolar light-regulated analogue of orexin-B.Cellular and molecular life sciences : CMLS · 2024Article
- An Ultrasensitive Biomimetic Optic Afferent Nervous System with Circadian Learnability.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Melanopsin-mediated optical entrainment regulates circadian rhythms in vertebrates.Communications biology · 2023Review
- Zebrafish as an Innovative Tool for Epilepsy Modeling: State of the Art and Potential Future Directions.International journal of molecular sciences · 2023Review
- Small Peptides Isolated from Enzymatic Hydrolyzate ofFoods (Basel, Switzerland) · 2023Article
- The Zebrafish, an Outstanding Model for Biomedical Research in the Field of Melatonin and Human Diseases.International journal of molecular sciences · 2022Review
- Modulation of sleep behavior in zebrafish larvae by pharmacological targeting of the orexin receptor.Frontiers in pharmacology · 2022Article
- An overview of the orexinergic system in different animal species.Metabolic brain disease · 2021Review
- Heterogeneity of Hypocretin/Orexin Neurons.Frontiers of neurology and neuroscience · 2021Review
- Melatonin modulates daytime-dependent synaptic plasticity and learning efficiency.Journal of pineal research · 2019Article
- Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons.Nature communications · 2019Article
- Contested Paradigm in Raising Zebrafish (Danio rerio).Zebrafish · 2018Article
- Neuronal noise as an origin of sleep arousals and its role in sudden infant death syndrome.Science advances · 2018Article
- Circadian Regulation of Hippocampal-Dependent Memory: Circuits, Synapses, and Molecular Mechanisms.Neural plasticity · 2018Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The circadian clock and homeostatic processes are fundamental mechanisms that regulate sleep. Surprisingly, despite decades of research, we still do not know why we sleep. Intriguing hypotheses suggest that sleep regulates synaptic plasticity and consequently has a beneficial role in learning and memory. However, direct evidence is still limited and the molecular regulatory mechanisms remain unclear. The zebrafish provides a powerful vertebrate model system that enables simple genetic manipulation, imaging of neuronal circuits and synapses in living animals, and the monitoring of behavioral performance during day and night. Thus, the zebrafish has become an attractive model to study circadian and homeostatic processes that regulate sleep. Zebrafish clock- and sleep-related genes have been cloned, neuronal circuits that exhibit circadian rhythms of activity and synaptic plasticity have been studied, and rhythmic behavioral outputs have been characterized. Integration of this data could lead to a better understanding of sleep regulation. Here, we review the progress of circadian clock and sleep studies in zebrafish with special emphasis on the genetic and neuroendocrine mechanisms that regulate rhythms of melatonin secretion, structural synaptic plasticity, locomotor activity and sleep.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.