ArticleCrystal growth & design2013
Complex Polymorphic System of Gallic Acid-Five Monohydrates, Three Anhydrates, and over 20 Solvates.
Article in Crystal growth & design, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 108 citations in OpenAlex.
- Unveiling Solvent-Mediated Mechanochemical Cocrystallization Pathways byMolecular pharmaceutics · 2026Article
- From polymorphs to cocrystals and salts: successfully predicting axitinib's challenging crystal forms.Chemical science · 2025Article
- Computation of the pMolecules (Basel, Switzerland) · 2025Article
- Phytochemistry, pharmacology, and medical uses of Oldenlandia (family Rubaceae): a review.Naunyn-Schmiedeberg's archives of pharmacology · 2024Review
- Frontiers of molecular crystal structure prediction for pharmaceuticals and functional organic materials.Chemical science · 2023Review
- Metronidazole Cocrystal Polymorphs with Gallic and Gentisic Acid Accessed through Slurry, Atomization Techniques, and Thermal Methods.Crystal growth & design · 2023Article
- Exploring the thermal behaviour of the solvated structures of nifedipine.Acta crystallographica Section B, Structural science, crystal engineering and materials · 2023Article
- The Conformations of Isolated Gallic Acid: A Laser-Ablation Rotational Study.Molecules (Basel, Switzerland) · 2022Article
- Thermochemical Transition in Low Molecular Weight Substances: The Example of the Silybin Flavonoid.Molecules (Basel, Switzerland) · 2022Article
- π-Hole bonding in a new co-crystal hydrate of gallic acid and pyrazine: static and dynamic charge density analysis.Acta crystallographica Section B, Structural science, crystal engineering and materials · 2022Article
- Periodic DFT Calculations-Review of Applications in the Pharmaceutical Sciences.Pharmaceutics · 2020Review
- Control and prediction of the organic solid state: a challenge to theory and experimentProceedings. Mathematical, physical, and engineering sciences · 2018Review
- Understanding the Role of Water in 1,10-Phenanthroline Monohydrate.CrystEngComm · 2017Article
- Stoichiometric and Non-Stoichiometric Hydrates of Brucine.Crystal growth & design · 2016Article
- 4-Aminoquinaldine monohydrate polymorphism: Prediction and impurity aided discovery of a difficult to access stable form.CrystEngComm · 2016Article
- Computational and Experimental Characterization of Five Crystal Forms of Thymine: Packing Polymorphism, Polytypism/Disorder and Stoichiometric 0.8-Hydrate.Crystal growth & design · 2016Article
- Structural Properties, Order-Disorder Phenomena, and Phase Stability of Orotic Acid Crystal Forms.Molecular pharmaceutics · 2016Article
- Article
- Navigating the Waters of Unconventional Crystalline Hydrates.Molecular pharmaceutics · 2015Article
- Solid state forms of 4-aminoquinaldine - From void structures with and without solvent inclusion to close packing.CrystEngComm · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report the structure of the fifth monohydrate of gallic acid and two additional anhydrate polymorphs and evidence of at least 22 other solvates formed, many containing water and another solvent. This unprecedented number of monohydrate polymorphs and diversity of solid forms is consistent with the anhydrate and monohydrate crystal energy landscapes, showing both a wide range of packing motifs and also some structures differing only in proton positions. By aiding the solution of structures from powder X-ray diffraction data and guiding the screening, the computational studies help explain the complex polymorphism of gallic acid. This is industrially relevant, as the three anhydrates are stable at ambient conditions but hydration/dehydration behavior is very dependent on relative humidity and phase purity.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.