ArticlePatient preference and adherence2013
Suboptimal treatment adherence in bipolar disorder: impact on clinical outcomes and functioning.
Article in Patient preference and adherence, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical and Sociodemographic Correlates of Poor Medication Adherence in People With Bipolar Disorder: A Systematic Review and Meta-Analysis.Bipolar disorders · 2026Pooled it
- Real-world adherence, healthcare resource utilization, and costs following a transition to aripiprazole once every 2 months among patients diagnosed with bipolar I disorder in the United States.Frontiers in psychiatry · 2026Article
- Ketogenic-Mimicking Diet as a Therapeutic Modality for Bipolar Disorder: Biomechanistic Rationale and Protocol for a Pilot Clinical Trial.Nutrients · 2023Article
- Evaluation of factors associated with medication adherence in patients with bipolar disorder using a medication event monitoring system: a 6-month follow-up prospective study.Annals of general psychiatry · 2022Article
- Identifying Poor Adherence in Outpatients with Bipolar Disorder: A Comparison of Different Measures.Journal of neurosciences in rural practice · 2022Article
- Antidepressant efficacy of low-frequency repetitive transcranial magnetic stimulation in antidepressant-nonresponding bipolar depression: a single-blind randomized sham-controlled trial.International journal of bipolar disorders · 2021Article
- Article
- Lifetime relapse and its associated factors among people with schizophrenia spectrum disorders who are on follow up at Comprehensive Specialized Hospitals in Amhara region, Ethiopia: a cross-sectional study.International journal of mental health systems · 2021Article
- Antipsychotic treatment experiences of people with bipolar I disorder: patient perspectives from an online survey.BMC psychiatry · 2020Article
- Psycho-demographic and clinical predictors of medication adherence in patients with bipolar I disorder in a university hospital in Egypt.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2020Article
- Medication nonadherence in bipolar disorder: a narrative review.Therapeutic advances in psychopharmacology · 2018Review
- Depressive residual symptoms are associated with illness course characteristics in a sample of outpatients with bipolar disorder.European archives of psychiatry and clinical neuroscience · 2018Article
- Atypical Antipsychotics and the Human Skeletal Muscle Lipidome.Metabolites · 2018Article
- Efficacy of shared decision-making on treatment adherence of patients with bipolar disorder: a cluster randomized trial (ShareD-BD).BMC psychiatry · 2018Article
- Long-term efficacy and safety of lamotrigine for all types of bipolar disorder.Neuropsychiatric disease and treatment · 2017Article
- Article
- Comparison of clinical outcomes with orodispersible versus standard oral olanzapine tablets in nonadherent patients with schizophrenia or bipolar disorder.Patient preference and adherence · 2017Article
- Treatment-adherence in bipolar disorder: A patient-centred approach.World journal of psychiatry · 2016Review
- Clinical significance of mobile health assessed sleep duration and variability in bipolar disorder.Journal of psychiatric research · 2016Article
- Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe primary aim of this study was to assess drug treatment adherence in patients with bipolar disorder and to identify factors associated with adherence. The secondary aim was to analyze the impact of suboptimal adherence on clinical and functional outcomes.
methodsA cross-sectional study was conducted in a sample of outpatients receiving an oral antipsychotic drug. Medication adherence was assessed combining the 10-item Drug Attitude Inventory, the Morisky Green Adherence Questionnaire, and the Compliance Rating Scale. Logistic regression was used to determine significant variables associated with suboptimal adherence to medication.
resultsThree hundred and three patients were enrolled into the study. The mean age was 45.9 ± 12.8 years, and 59.7% were females. Sixty-nine percent of patients showed suboptimal adherence. Disease severity and functioning were significantly worse in the suboptimal group than in the adherent group. Multivariate analysis showed depressive polarity of the last acute episode, presence of subsyndromal symptoms, and substance abuse/dependence to be significantly associated with suboptimal treatment adherence (odds ratios 3.41, 2.13, and 1.95, respectively).
conclusionA high prevalence of nonadherence was found in an outpatient sample with bipolar disorder. Identification of factors related to treatment adherence would give clinicians the opportunity to select more adequately patients who are eligible for potential adherence-focused interventions.
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