ArticleDiabetes care2013
Proinflammatory cytokines, adiponectin, and increased risk of primary cardiovascular events in diabetic patients with or without renal dysfunction: results from the ESTHER study.
Article in Diabetes care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Association between adiponectin concentrations and cardiovascular disease in diabetic patients: a systematic review and meta-analysis.PloS one · 2013Pooled it
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- Body mass index across adulthood, weight gain and cancer risk: a population-based cohort study.BMC cancer · 2025Article
- Improving 10-year cardiovascular risk prediction in patients with type 2 diabetes with metabolomics.Cardiovascular diabetology · 2025Article
- Physical Activity as a Modern Intervention in the Fight against Obesity-Related Inflammation in Type 2 Diabetes Mellitus and Gestational Diabetes.Antioxidants (Basel, Switzerland) · 2023Review
- Plasma Interleukin-6 Level Predicts the Risk of Arteriovenous Fistula Dysfunction in Patients Undergoing Maintenance Hemodialysis.Journal of personalized medicine · 2023Article
- The synergistic compatibility mechanisms of fuzi against chronic heart failure in animals: A systematic review and meta-analysis.Frontiers in pharmacology · 2022Review
- Urinary IL-18 is associated with arterial stiffness in patients with type 2 diabetes.Frontiers in endocrinology · 2022Article
- What Links an Increased Cardiovascular Risk and Inflammatory Bowel Disease? A Narrative Review.Nutrients · 2021Review
- Circulating Vascular Adhesion Protein-1 Level Predicts the Risk of Cardiovascular Events and Mortality in Hemodialysis Patients.Frontiers in cardiovascular medicine · 2021Article
- Sex-, Age-, and Metabolic Disorder-Dependent Distributions of Selected Inflammatory Biomarkers among Community-Dwelling Adults.Diabetes & metabolism journal · 2020Article
- Adipokines and Obesity. Potential Link to Metabolic Disorders and Chronic Complications.International journal of molecular sciences · 2020Review
- Higher circulating omentin is associated with increased risk of primary cardiovascular events in individuals with diabetes.Diabetologia · 2020Article
- Lower Levels of Circulating Adiponectin in Elderly Patients with Metabolic Inflammatory Syndrome: A Cross-Sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Influence of micro- and macro-vascular disease and Tumor Necrosis Factor Receptor 1 on the level of lower-extremity amputation in patients with type 2 diabetes.Cardiovascular diabetology · 2018Article
- Adiponectin, biomarkers of inflammation and changes in cardiac autonomic function: Whitehall II study.Cardiovascular diabetology · 2017Article
- Hyperglycaemia, oxidative stress and inflammatory markers.Redox report : communications in free radical research · 2017Article
- ANGPTL2 is associated with an increased risk of cardiovascular events and death in diabetic patients.Diabetologia · 2016Article
- Prognostic Importance of C-Reactive Protein in High Cardiovascular Risk Patients With Type 2 Diabetes Mellitus: The Rio de Janeiro Type 2 Diabetes Cohort Study.Journal of the American Heart Association · 2016Observational
- Pneumonia in the Noninstitutionalized Older Population.Deutsches Arzteblatt international · 2016Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveInflammatory processes contribute to both diabetes and cardiovascular risk. We wanted to investigate whether circulating concentrations of proinflammatory immune mediators and adiponectin in diabetic patients are associated with incident cardiovascular events. RESEARCH DESIGN AND
methodsIn 1,038 participants with diabetes of the population-based ESTHER study, of whom 326 showed signs of renal dysfunction, Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% CIs for the association of increasing concentrations of C-reactive protein (CRP), interleukin-6 (IL-6), IL-18, macrophage migration inhibitory factor (MIF), adiponectin, and leptin with cardiovascular events (myocardial infarction, stroke, or fatal cardiovascular event) during a follow-up period of 8 years.
resultsDuring follow-up, 161 subjects with diabetes experienced a primary cardiovascular event. Proinflammatory markers were not associated with a higher risk for primary cardiovascular events in the total study population after adjustment for multiple confounders. However, IL-6 and MIF were associated with cardiovascular events in subjects with renal dysfunction (HR for the comparison of top vs. bottom tertile 1.98 [95% CI 1.12-3.52], P [trend] = 0.10 for IL-6; 1.48 [0.87-2.51], P [trend] = 0.04 for MIF). Adiponectin levels were associated with cardiovascular events in the total population (1.48 [1.01-2.21], P [trend] = 0.03), and the association was even more pronounced in the subgroup with renal dysfunction (1.97 [1.08-3.57], P [trend] = 0.02).
conclusionsIn particular, the absence of an association between CRP and a U-shaped association of adiponectin levels with incident cardiovascular events show that associations between circulating immune mediators and cardiovascular risk differ between diabetic patients and subjects of the general population.
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