ArticleMolecular imaging and biology2013
Evaluation of inflammatory response to acute ischemia using near-infrared fluorescent reactive oxygen sensors.
Article in Molecular imaging and biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- ROS-Activatable J‑Aggregate Formation of a NIR-II Fluorescent Sensor for Detecting and Imaging Oxidative Stress-Associated Diseases In Vivo.Chemical & biomedical imaging · 2026Article
- Grape polyphenols reduce gut-localized reactive oxygen species associated with the development of metabolic syndrome in mice.PloS one · 2018Article
- Non-Invasive Monitoring of CNS MHC-I Molecules in Ischemic Stroke Mice.Theranostics · 2017Article
- Imaging of radicals following injury or acute stress in peripheral nerves with activatable fluorescent probes.Free radical biology & medicine · 2016Article
- In vivo retinal and choroidal hypoxia imaging using a novel activatable hypoxia-selective near-infrared fluorescent probe.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2016Article
- Methods for measuring myeloperoxidase activity toward assessing inhibitor efficacy in living systems.Journal of leukocyte biology · 2016Review
- Polymeric Nanostructures for Imaging and Therapy.Chemical reviews · 2015Review
- In Vivo Imaging of Retinal Oxidative Stress Using a Reactive Oxygen Species-Activated Fluorescent Probe.Investigative ophthalmology & visual science · 2015Article
- Cyanine polyene reactivity: scope and biomedical applications.Organic & biomolecular chemistry · 2015Review
- Visualization of pulmonary clearance mechanisms via noninvasive optical imaging validated by near-infrared flow cytometry.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2015Article
- Holistic assessment of covalently labeled core-shell polymeric nanoparticles with fluorescent contrast agents for theranostic applications.Langmuir : the ACS journal of surfaces and colloids · 2014Article
- Saccharide substituted zinc phthalocyanines: optical properties, interaction with bovine serum albumin and near infrared fluorescence imaging for sentinel lymph nodes.Molecules (Basel, Switzerland) · 2014Article
- Synthesis of nitric oxide probes with fluorescence lifetime sensitivity.Organic & biomolecular chemistry · 2013Article
- Sensitivity of activatable reactive oxygen species probes by fluorescence spectroelectrochemistry.The Analyst · 2013Article
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Authors and funding
7 authors.
Funding
Abstract
purposeIschemia-related processes associated with the generation of inflammatory molecules such as reactive oxygen species (ROS) are difficult to detect at the acute stage before the physiologic and anatomic evidence of tissue damage is present. Evaluation of the inflammatory and healing response early after an ischemic event in vivo will aid in treatment selection and patient outcomes. We introduce a novel near-infrared hydrocyanine molecular probe for the detection of ROS as a marker of tissue response to ischemia and a precursor to angiogenesis and remodeling. The synthesized molecular probe, initially a non-fluorescent hydrocyanine conjugated to polyethylene glycol, converts to a highly fluorescent cyanine reporter upon oxidation. PROCEDURES: The probe was applied in a preclinical mouse model for myocardial infarction, where ligation and removal of a portion of the femoral artery in the hindlimb resulted in temporary ischemia followed by angiogenesis and healing.
resultsThe observed increase in fluorescence intensity was approximately sixfold over 24 h in the ischemic tissue relative to the uninjured control limb and was attributed to the higher concentration of ROS in the ischemic tissue.
conclusionsThese results demonstrate the potential for non-invasive sensing for interrogating the inflammatory and healing response in ischemic tissue.
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