ArticleCancer causes & control : CCC2013
The 2011-2016 Transdisciplinary Research on Energetics and Cancer (TREC) initiative: rationale and design.
Article in Cancer causes & control : CCC, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Team science as interprofessional collaborative research practice: a systematic review of the science of team science literature.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2017Pooled it
- The women in steady exercise research (WISER) survivor trial: The innovative transdisciplinary design of a randomized controlled trial of exercise and weight-loss interventions among breast cancer survivors with lymphedema.Contemporary clinical trials · 2017Trial
- Recruitment strategies, design, and participant characteristics in a trial of weight-loss and metformin in breast cancer survivors.Contemporary clinical trials · 2016Trial
- Objectively measured physical activity and cognitive functioning in breast cancer survivors.Journal of cancer survivorship : research and practice · 2015Trial
- Changes in activity spaces, life spaces, and exposures to physical activity-promoting environments among women with overweight or obesity.Health & place · 2025Article
- The Cancer Survivorship Program at the Abramson Cancer Center of the University of Pennsylvania.Journal of cancer survivorship : research and practice · 2024Review
- Key takeaways for knowledge expansion of early-career scientists conducting Transdisciplinary Research in Energetics and Cancer (TREC): a report from the TREC Training Workshop 2022.Journal of the National Cancer Institute. Monographs · 2023Article
- Translational and transdisciplinary research in energy balance and cancer: past is prologue.Journal of the National Cancer Institute. Monographs · 2023Article
- GPS-based activity space exposure to greenness and walkability is associated with increased accelerometer-based physical activity.Environment international · 2022Article
- Re-orienting transdisciplinary research and community-based participatory research for health equity.Journal of clinical and translational science · 2022Article
- Transdisciplinary Research in Energetics and Cancer early career investigator training program: first year results.Translational behavioral medicine · 2021Article
- Facilitating cancer systems epidemiology research.PloS one · 2021Article
- Transdisciplinary research outcomes based on the Transdisciplinary Research on Energetics and Cancer II initiative experience.Research Evaluation · 2021Article
- A critical realist synthesis of cross-disciplinary health policy and systems research: defining characteristic features, developing an evaluation framework and identifying challenges.Health research policy and systems · 2020Review
- Drivers of cost differences between US breast cancer survivors with or without lymphedema.Journal of cancer survivorship : research and practice · 2019Article
- A framework for coordination center responsibilities and performance in a multi-site, transdisciplinary public health research initiative.Research Evaluation · 2019Article
- Observational
- "It still affects our economic situation": long-term economic burden of breast cancer and lymphedema.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Article
- Associations Between Timing of Meals, Physical Activity, Light Exposure, and Sleep With Body Mass Index in Free-Living Adults.Journal of physical activity & health · 2019Article
- Zeitgebers and their association with rest-activity patterns.Chronobiology international · 2019Article
Corrections and comments
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Authors and funding
45 authors.
Funding
Abstract
purposeRecognition of the complex, multidimensional relationship between excess adiposity and cancer control outcomes has motivated the scientific community to seek new research models and paradigms.
methodsThe National Cancer Institute developed an innovative concept to establish a center grant mechanism in nutrition, energetics, and physical activity, referred to as the Transdisciplinary Research on Energetics and Cancer (TREC) Initiative. This paper gives an overview of the 2011-2016 TREC Collaborative Network and the 15 research projects being conducted at the centers.
resultsFour academic institutions were awarded TREC center grants in 2011: Harvard University, University of California San Diego, University of Pennsylvania, and Washington University in St. Louis. The Fred Hutchinson Cancer Research Center is the Coordination Center. The TREC research portfolio includes three animal studies, three cohort studies, four randomized clinical trials, one cross-sectional study, and two modeling studies. Disciplines represented by TREC investigators include basic science, endocrinology, epidemiology, biostatistics, behavior, medicine, nutrition, physical activity, genetics, engineering, health economics, and computer science. Approximately 41,000 participants will be involved in these studies, including children, healthy adults, and breast and prostate cancer survivors. Outcomes include biomarkers of cancer risk, changes in weight and physical activity, persistent adverse treatment effects (e.g., lymphedema, urinary and sexual function), and breast and prostate cancer mortality.
conclusionThe NIH Science of Team Science group will evaluate the value added by this collaborative science. However, the most important outcome will be whether this transdisciplinary initiative improves the health of Americans at risk of cancer as well as cancer survivors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.