ArticleInternational journal of colorectal disease2013
Neuroendocrine markers and psychological features in patients with irritable bowel syndrome.
Article in International journal of colorectal disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 35 citations in OpenAlex.
- Digestive Manifestations of Post-COVID-19: A Focus on Therapeutic Strategies.Pathogens (Basel, Switzerland) · 2025Review
- Associations of Schizophrenia and Major Depressive Disorder with Constipation: A Mendelian Randomization Study.Clinical and experimental gastroenterology · 2024Article
- Intrinsic brain abnormalities of irritable bowel syndrome with diarrhea: a preliminary resting-state functional magnetic resonance imaging study.BMC medical imaging · 2021Article
- Effects of Psychological and Physical Stress on Oxidative Stress, Serotonin, and Fatigue in Young Females Induced by Objective Structured Clinical Examination: Pilot Study of u-8-OHdG, u-5HT, and s-HHV-6.International journal of tryptophan research : IJTR · 2021Article
- Gut Biofactory-Neurocompetent Metabolites within the Gastrointestinal Tract. A Scoping Review.Nutrients · 2020Article
- Neuroendocrine Dysregulation in Irritable Bowel Syndrome Patients: A Pilot Study.Journal of neurogastroenterology and motility · 2017Article
- Subthreshold Psychiatric Psychopathology in Functional Gastrointestinal Disorders: Can It Be the Bridge between Gastroenterology and Psychiatry?Gastroenterology research and practice · 2017Article
- The Role ofGastroenterology research and practice · 2016Review
- Irritable bowel syndrome and chronic constipation: Fact and fiction.World journal of gastroenterology · 2015Review
- Advances in the management of constipation-predominant irritable bowel syndrome: the role of linaclotide.Therapeutic advances in gastroenterology · 2014Review
- Irritable bowel syndrome: a disease still searching for pathogenesis, diagnosis and therapy.World journal of gastroenterology · 2014Review
- Serotonin receptors and their role in the pathophysiology and therapy of irritable bowel syndrome.Techniques in coloproctology · 2014Review
- Irritable bowel syndrome is associated not only with organic but also psychogenic erectile dysfunction.International journal of impotence researchArticle
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsThe key role of the brain-gut axis in the pathophysiology of irritable bowel syndrome (IBS) has been recognized. The aim of this study was to assess the possible association between IBS, neuroendocrine markers, and psychological features.
methodsOne hundred and twenty-five consecutive IBS patients and 105 healthy subjects were enrolled. Plasma serotonin, plasma and urinary cortisol, and plasma neuropeptide Y levels were evaluated. All patients were given a questionnaire to assess IBS symptom severity. In 66 patients, a psychodiagnostic assessment was carried out.
resultsA high incidence of specific psychological features, including state anxiety (69.69 %), trait anxiety (54.54 %), obsessions and compulsions (28.78 %), was observed in IBS patients. A positive correlation between neuropeptide Y and state anxiety (r = 0.287, p = 0.024) and simulation/social ingenuity (r = 0.269, p = 0.039) was found in these patients. In diarrhea-predominant IBS, plasma cortisol was linearly related to plasma serotonin (r = 0.5663, p < 0.001).
conclusionsIn IBS patients, a significant correlation was found between specific psychological features and neuroendocrine markers, especially plasma cortisol and neuropeptide Y; in diarrhea-predominant IBS, a correlation between plasma cortisol and serotonin was found, although it needs to be confirmed in more extensive cohorts.
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