ArticleEndocrine2013
Association between bisphenol A and abnormal free thyroxine level in men.
Article in Endocrine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Bisphenol A exposure and associations with obesity among adults: a critical review.Public health nutrition · 2015Pooled it
- Bisphenol A and its analogues in thyroid diseases: Evidence from dysfunction, autoimmunity, and cancer.iScience · 2026Review
- Review
- Differences in autoimmune thyroid diseases between females and males: the result of a complex interconnection of factors.Endocrine · 2025Review
- Article
- Exogenous Melatonin Protects against Oxidative Damage to Membrane Lipids Caused by Some Sodium/Iodide Symporter Inhibitors in the Thyroid.Antioxidants (Basel, Switzerland) · 2023Article
- Re-evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs.EFSA journal. European Food Safety Authority · 2023Article
- Review
- Review
- Impact of Chemical Endocrine Disruptors and Hormone Modulators on the Endocrine System.International journal of molecular sciences · 2022Review
- Environmental Factors Affecting Thyroid-Stimulating Hormone and Thyroid Hormone Levels.International journal of molecular sciences · 2021Review
- Bisphenols as Environmental Triggers of Thyroid Dysfunction: Clues and Evidence.International journal of environmental research and public health · 2020Review
- Maternal environmental exposure to bisphenols and epigenome-wide DNA methylation in infant cord blood.Environmental epigenetics · 2020Article
- Bisphenols and Thyroid Hormone.Endocrinology and metabolism (Seoul, Korea) · 2019Review
- Thyroid-disrupting chemicals and brain development: an update.Endocrine connections · 2018Review
- Disruption in Thyroid Signaling Pathway: A Mechanism for the Effect of Endocrine-Disrupting Chemicals on Child Neurodevelopment.Frontiers in endocrinology · 2018Review
- Thyroid hormone parameters during pregnancy in relation to urinary bisphenol A concentrations: A repeated measures study.Environment international · 2017Article
- Accelerated reduction of serum thyroxine and hippocampal histone acetylation links to exacerbation of spatial memory impairment in aged CD-1 mice pubertally exposed to bisphenol-a.Age (Dordrecht, Netherlands) · 2016Article
- The Association of Serum Bisphenol A with Thyroid Autoimmunity.International journal of environmental research and public health · 2016Article
- Estimating bisphenol A exposure levels using a questionnaire targeting known sources of exposure.Public health nutrition · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bisphenol A (BPA) is a chemical that is used in a variety of consumer products, and exposure to BPA is widespread among the general population. Recent studies have suggested that BPA may affect the thyroid and related pathways. However, human studies are still limited. The aim of this study was to determine the relationship between BPA exposure and thyroid function. We obtained survey data and blood samples from The Thai National Health Examination Survey IV 2009, a nationally representative cross-sectional survey using a multistage, stratified sampling of the Thai population. A total of 2,340 subjects aged 18-94 years were sampled for the present study. Serum BPA, TSH, FT4, and related covariates were measured. BPA was log-transformed prior to analysis. BPA was detected in 52.8 % of serum samples with a median concentration of 0.33 (range 0-66.91) ng/mL. We excluded subjects who tested positive for thyroid autoantibody and then stratified the remaining subjects by gender; the analysis showed a significantly negative correlation between serum BPA and FT4 levels in males (r = -0.14, P < 0.001). In contrast, no association was observed in females. BPA was not associated with TSH in either gender. This gender-related discrepancy is possibly related to androgen-related differences in the metabolism of BPA. Our preliminary results provide evidence of a negative association between BPA and FT4 levels. Additional detailed studies are needed to investigate the temporal relationship and potential public health implications of such an association.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.