ArticlePediatric radiology2013
Dynamic contrast-enhanced MRI improves accuracy for detecting focal splenic involvement in children and adolescents with Hodgkin disease.
Article in Pediatric radiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Whole-Body MRI Is an Effective Imaging Modality for Hematological Malignancy Treatment Response Assessment: A Systematic Review and Meta-Analysis.Frontiers in oncology · 2022Pooled it
- Whole-body magnetic resonance imaging in children - how and why? A systematic review.Pediatric radiology · 2021Pooled it
- Whole-body magnetic resonance imaging for detection of skeletal metastases in children and young people with primary solid tumors - systematic review.Pediatric radiology · 2018Pooled it
- Assessment of the nature of residual masses at end of treatment in lymphoma patients using volume perfusion computed tomography.European radiology · 2014Trial
- Diagnostic performance of different imaging modalities for splenic malignancies: A comparative meta-analysis.European journal of radiology open · 2024Article
- Intravoxel incoherent motion diffusion-weighted MRI for the evaluation of early spleen involvement in acute leukemia.Quantitative imaging in medicine and surgery · 2024Article
- Article
- Optimized Whole-Body PET MRI Sequence Workflow in Pediatric Hodgkin Lymphoma Patients.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023Article
- Whole-Body Magnetic Resonance Imaging: Current Role in Patients with Lymphoma.Diagnostics (Basel, Switzerland) · 2021Review
- Whole-body magnetic resonance imaging (WB-MRI) in oncology: an Italian survey.La Radiologia medica · 2021Article
- Whole-body magnetic resonance imaging in pediatric oncology - recommendations by the Oncology Task Force of the ESPR.Pediatric radiology · 2020Article
- Imaging features of extranodal involvement in paediatric Hodgkin lymphoma.Pediatric radiology · 2019Review
- Combined PET/MR: The Real Work Has Just Started. Summary Report of the Third International Workshop on PET/MR Imaging; February 17-21, 2014, Tübingen, Germany.Molecular imaging and biology · 2015Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAccurate assessment of splenic disease is important for staging Hodgkin lymphoma.
objectiveThe purpose of this study was to assess T2-weighted imaging with and without dynamic contrast-enhanced (DCE) MRI for evaluation of splenic Hodgkin disease. MATERIALS AND
methodsThirty-one children with Hodgkin lymphoma underwent whole-body T2-weighted MRI with supplementary DCE splenic imaging, and whole-body PET-CT before and following chemotherapy. Two experienced nuclear medicine physicians derived a PET-CT reference standard for splenic disease, augmented by follow-up imaging. Unaware of the PET-CT, two experienced radiologists independently evaluated MRI exercising a locked sequential read paradigm (T2-weighted then DCE review) and recorded the presence/absence of splenic disease at each stage. Performance of each radiologist was determined prior to and following review of DCE-MRI. Incorrect MRI findings were ascribed to reader (lesion present on MRI but missed by reader) or technical (lesion not present on MRI) error.
resultsSeven children had splenic disease. Sensitivity/specificity of both radiologists for the detection of splenic involvement using T2-weighted images alone was 57%/100% and increased to 100%/100% with DCE-MRI. There were three instances of technical error on T2-weighted imaging; all lesions were visible on DCE-MRI.
conclusionsT2-weighted imaging when complemented by DCE-MRI imaging may improve evaluation of Hodgkin disease splenic involvement.
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Registered trials
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