Trial reportEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2013
The high-risk discectomy patient: prevention of reherniation in patients with large anular defects using an anular closure device.
Trial report in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01534065 (A Multi-center, Post Marketing Surveillance Study to Monitor the Safety and Performance of the Barricaid® ARD in the Treatment of Back and Radicular Pain Caused by Primary Lumbar Disc Herniation), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multi-center, Post Marketing Surveillance Study to Monitor the Safety and Performance of the Barricaid® ARD in the Treatment of Back and Radicular Pain Caused by Primary Lumbar Disc Herniation
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Annular closure device for disc herniation: meta-analysis of clinical outcome and complications.BMC musculoskeletal disorders · 2018Pooled it
- Risk factors for early reherniation after lumbar discectomy with or without annular closure: results of a multicenter randomized controlled study.Acta neurochirurgica · 2021Trial
- Three-year results from a randomized trial of lumbar discectomy with annulus fibrosus occlusion in patients at high risk for reherniation.Acta neurochirurgica · 2019Trial
- Mechanical and Biological Treatments for Annulus Fibrosus Repair and Closure: A Review of Clinical Studies.Neurospine · 2026Review
- Beyond Pain Relief: Preventing Recurrence and Preserving Function After Lumbar Discectomy.International journal of spine surgery · 2025Article
- Annular Closure Device Reduces Symptomatic Reherniation Rates: Results of a Meta-analysis.HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2025Article
- Current Therapeutic Strategies of Intervertebral Disc Regenerative Medicine.Molecular diagnosis & therapy · 2024Review
- Bone-anchored annular closure device leading to histiocytic-inflammation-induced neuropathy with resolution after removal: a case report.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024Article
- AnJOR spine · 2023Article
- Intraoperative findings, complications, and short-term results after lumbar microdiscectomy with or without implantation of annular closure device.Acta neurochirurgica · 2021Article
- Needle-Guided Suture Technique for Lumbar Annular Fiber Closure in Microendoscopic Discectomy: A Technical Note and Case Series.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Efficacy of a Novel Annular Closure Device after Lumbar Discectomy in Korean Patients : A 24-Month Follow-Up of a Randomized Controlled Trial.Journal of Korean Neurosurgical Society · 2019Article
- A Heterologous Fibrin Glue Enhances the Closure Effect of Surgical Suture on the Repair of Annulus Fibrous Defect in a Sheep Model.Current medical science · 2019Article
- The Disability Cascade: A Preventable Consequence of the Loss of Disc Height following Lumbar Microdiscectomy.Cureus · 2019Review
- Review
- Effects of Level, Loading Rate, Injury and Repair on Biomechanical Response of Ovine Cervical Intervertebral Discs.Annals of biomedical engineering · 2018Article
- Implantation of a bone-anchored annular closure device in conjunction with tubular minimally invasive discectomy for lumbar disc herniation: a retrospective study.BMC musculoskeletal disorders · 2018Article
- Feasibility of the annulus fibrosus repair with in situ gelating hydrogels - A biomechanical study.PloS one · 2018Article
- Performance of an Annular Closure Device in a 'Real-World', Heterogeneous, At-Risk, Lumbar Discectomy Population.Cureus · 2017Article
- Sciatica caused by disc herniation: Why is Chymopapain Chemonucleolysis denied to our patients?International journal of spine surgery · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWith lumbar discectomy for disc herniation, surgeons must choose between limited nucleus removal associated with higher reherniation risk or more aggressive nucleus removal associated with increased back pain and disc degeneration. This trade-off is particularly challenging in patients with large anular defects, which carry the highest risk of reherniation. We examined the effect of an anular closure device on reherniation and clinical outcomes.
methodsSeventy-five primary discectomy patients had a limited discectomy followed by implantation of an anular closure device and were followed-up to 2 years. Anular defect size and volume of removed nucleus was recorded at surgery. Reherniations were reported, pain and function were monitored throughout, and imaging was performed at annual visits.
resultsThe overall symptomatic reherniation rate was 1.4%, and the asymptomatic reherniation rate was 1.5% at 12 months and 5.1% at 24 months. Both rates compare favorably with literature reports which include symptomatic rates ranging between 2 and 18% (up to 27% for patients with large anular defects) and an asymptomatic rate of 13%.
conclusionsThe low reherniation rate in patients at high-risk of reherniation based on anular defect size, despite discectomy being only limited, suggests that an anular closure device may reduce reherniation risk. Clinical outcomes for pain and function at 1 and 2 years post-operatively compared favorably with literature reports. Further study in a randomized controlled trial is required to confirm these results.
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