Evidence map›Paper›PMID 23377349›Full record

ArticleSchmerz (Berlin, Germany)2013

[Rapid release fentanyl administration forms. Comments of the Working Group on Tumor Pain of the German Pain Society].

S Wirz, C H R Wiese, M Zimmermann, U Junker, E Heuser-Grannemann, M Schenk

Abstract read
PubMed Publisher
In one paragraph

Article in Schmerz (Berlin, Germany), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

S WirzAbteilung für Anästhesie, Interdisziplinäre Intensivmedizin, Schmerztherapie, Palliativmedizin, CURA Kath. Krankenhaus im Siebengebirge, Schülgenstr. 15, 53604, Bad Honnef, Deutschland. stefan.wirz@cura.org
C H R Wiese
M Zimmermann
U Junker
E Heuser-Grannemann
M Schenk

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The spectrum of indications for rapid release fentanyl preparations is controversial. For this reason the Working Group on Tumor Pain will formulate comments on how to deal with these substances. Breakthrough pain should receive individualized therapy; therefore, the use of opioids of various galenic formulations seems to be advisable. New rapid release fentanyl preparations are suitable for alleviating spontaneous breakthrough pain in tumor patients due to a rapid but short-acting effect. However, a prior optimization of the analgesic basis medication is absolutely necessary. Uncontrolled prescription for non-cancer pain must be criticized due to the problem of addiction. The medical profession should be informed about the benefits of rapid release fentanyl preparations but must also be made aware of the risk of a rapid development of addiction and tolerance. A self-commitment of the pharmaceutical industry to waive advertising for the dangerous off-label use would be desirable. In the opinion of the Working Group on Tumor Pain the use of fentanyl should be openly discussed and further scientific investigations are imperative with the aim of formulating clear recommendations.

Indexed as

Societies, MedicalAdvertisingAnalgesics, OpioidBreakthrough PainDrug IndustryDrug ToleranceEducationFentanylGermanyHumansNeoplasmsOff-Label UseOpioid-Related DisordersRisk FactorsAnalgesics, OpioidFentanyl

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.