ArticleMedical science monitor : international medical journal of experimental and clinical research2013
Quantitative MR evaluation of atrophy, as well as perfusion and diffusion alterations within hippocampi in patients with Alzheimer's disease and mild cognitive impairment.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
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- Selective Ability of Some CANTAB Battery Test Measures to Detect Cognitive Response to a Single Dose of Donepezil in Alzheimer Disease.Medical science monitor : international medical journal of experimental and clinical research · 2015Trial
- Evaluation of Fundus Blood Flow Perfusion in Patients with Diabetic Retinopathy after PPV with Fundus Color Doppler Based on Big Data Mining.Journal of healthcare engineering · 2022Article
- Brain atrophy pattern in patients with mild cognitive impairment: MRI study.Translational neuroscience · 2022Article
- Identification and Classification of Alzheimer's Disease Patients Using Novel Fractional Motion Model.Frontiers in neuroscience · 2020Article
- Characterization of Alzheimer's Disease Using Ultra-high b-values Apparent Diffusion Coefficient and Diffusion Kurtosis Imaging.Aging and disease · 2019Article
- AVRA: Automatic visual ratings of atrophy from MRI images using recurrent convolutional neural networks.NeuroImage. Clinical · 2019Article
- Multi-modal MRI investigation of volumetric and microstructural changes in the hippocampus and its subfields in mild cognitive impairment, Alzheimer's disease, and dementia with Lewy bodies.International psychogeriatrics · 2017Article
- Quantitative multimodal multiparametric imaging in Alzheimer's disease.Brain informatics · 2016Article
- Interleukin-1beta-induced reduction of tissue water diffusion in the juvenile rat brain on ADC MRI is not associated with (31)P MRS-detectable energy failure.Journal of inflammation (London, England) · 2016Article
- Factors related to long-term post-stroke cognitive impairment in young adult ischemic stroke.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Glucose metabolism measured by positron emission tomography is reduced in patients with white matter presumably ischemic lesions.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
- Omental transplantation for neurodegenerative diseases.American journal of neurodegenerative disease · 2014Review
- Plasma cortisol in Alzheimer's disease with or without depressive symptoms.Medical science monitor : international medical journal of experimental and clinical research · 2013Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to evaluate atrophy rates, perfusion, and diffusion disturbances within the hippocampus, which is the site of characteristic changes in Alzheimer's disease (AD) and mild cognitive impairment (MCI). MATERIAL AND
methodsThirty patients with AD (mean age 71.2 yrs) - 34 with MCI (mean age 67.7 yrs) and 20 healthy controls (mean age 68.1 yrs) - underwent structural MR examination followed by perfusion and diffusion-weighted imaging on a 1.5 T scanner. Visual rating of hippocampal atrophy, planimetric measurements of hippocampal formation (HF) and perihippocampal fluid spaces (PFSs), and values of relative cerebral blood volume (rCBV) and apparent diffusion coefficient (ADC) were assessed. The results were correlated with the MMSE scores.
resultsIn AD we found decreased size of HF and increased diameters of PFSs and ADC values, compared to MCI and control group. Compared to normal controls, the MCI group showed decreased HF size and increased diameters of only medial PFS. There were no differences in rCBV values among all the subject groups. Planimetric measurements of hippocampal atrophy showed the highest accuracy in diagnosing AD and MCI. In all patients, the increased rates of hippocampal atrophy correlated with the increased ADC values. In MCI, MMSE scores correlated with the HF size and ADC values.
conclusionsIn AD and MCI, hippocampal atrophy is associated with decreased tissue integrity without coexisting perfusion disturbances. Of all evaluated hippocampal measurements, atrophy rates seem to be the most useful parameters in detecting changes among AD, MCI, and control subjects.
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