Evidence map›Paper›PMID 23377027›Full record

ArticleNature cell biology2013

Osmotic regulation of seamless tube growth.

Jodi Schottenfeld-Roames, Amin S Ghabrial

Abstract readComment
In one paragraph

Article in Nature cell biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. OSM-11 modulates salinity-stress tolerance inbioRxiv : the preprint server for biology · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Molecular mechanisms of de novo lumen formation.Nature reviews. Molecular cell biology · 2014
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Jodi Schottenfeld-RoamesDepartment of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA.
Amin S Ghabrial

Funding

Competition and morphogenesis in tip cell-mediated branching of tubular networksR01GM089782 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI GHABRIAL, AMIN S · 2010 to 2022
$4.2M
NIGMS NIH HHS R01 GM089782
6 · The paper itself

Abstract

Most organs are composed of tubes of differing cellular architectures, including intracellular 'seamless' tubes. Two studies examining the morphogenesis of the seamless tubes formed by the excretory canal cell in Caenorhabditis elegans reveal a previously unappreciated role for osmoregulation of tubulogenesis: hyperosmotic shock recruits canalicular vesicles to the lumenal membrane to promote seamless tube growth.

Indexed as

LymphangiogenesisWater-Electrolyte BalanceAnimalsAquaporinsCaenorhabditis elegansCaenorhabditis elegans ProteinsCell MembraneCytoskeletal ProteinsHomeodomain ProteinsHumansLymphatic VesselsProspero-Related Homeobox 1 ProteinTumor Suppressor Proteinsaquaporin 8AquaporinsCaenorhabditis elegans ProteinsCytoskeletal ProteinsERM-1 protein, C elegansHomeodomain ProteinsProspero-Related Homeobox 1 ProteinTumor Suppressor Proteins

Identifiers

PMID23377027
PMCPMC4520389

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.