ArticleEukaryotic cell2013
Extremely reduced levels of heterozygosity in the vertebrate pathogen Encephalitozoon cuniculi.
Article in Eukaryotic cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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Who cites it
29 citing papers in PubMed.
- In vitro culture of human-infecting Encephalitozoon spp. for genome sequencing with minimal host contaminant.PloS one · 2026Article
- Assembly collapsing versus heterozygosity oversizing: detection of homokaryotic and heterokaryoticMicrobial genomics · 2024Article
- Polyploidy is widespread in Microsporidia.Microbiology spectrum · 2024Article
- Draft genome assemblies of the avian louse Brueelia nebulosa and its associates using long-read sequencing from an individual specimen.G3 (Bethesda, Md.) · 2023Article
- Morphological characterization and genetic diversity of a new microsporidium,Frontiers in cellular and infection microbiology · 2023Article
- Comparative Genomics of Microsporidia.Experientia supplementum (2012) · 2022Article
- Sparse Evidence forPathogens (Basel, Switzerland) · 2021Article
- Evolution of microsporidia: An extremely successful group of eukaryotic intracellular parasites.PLoS pathogens · 2020Article
- Microsporidia with Vertical Transmission Were Likely Shaped by Nonadaptive Processes.Genome biology and evolution · 2020Article
- Are molecular tools clarifying or confusing our understanding of the public health threat from zoonotic enteric protozoa in wildlife?International journal for parasitology. Parasites and wildlife · 2019Review
- Genetic and Genome Analyses Reveal Genetically Distinct Populations of the Bee Pathogen Nosema ceranae from Thailand.Microbial ecology · 2019Article
- The genome of an intranuclear parasite,eLife · 2017Article
- Dynamics of parasitophorous vacuoles formed by the microsporidian pathogen Encephalitozoon cuniculi.Fungal genetics and biology : FG & B · 2017Article
- Microsporidia: Obligate Intracellular Pathogens Within the Fungal Kingdom.Microbiology spectrum · 2017Review
- Fungal Sex: The Mucoromycota.Microbiology spectrum · 2017Review
- Genome Analysis of Pseudoloma neurophilia: A Microsporidian Parasite of Zebrafish (Danio rerio).The Journal of eukaryotic microbiology · 2017Article
- Genetic diversity of two Daphnia-infecting microsporidian parasites, based on sequence variation in the internal transcribed spacer region.Parasites & vectors · 2016Article
- Article
- More than a rabbit's tale -International journal for parasitology. Parasites and wildlife · 2016Review
- The Development of Genetic Modification Techniques in Intracellular Parasites and Potential Applications to Microsporidia.PLoS pathogens · 2015Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The genomes of microsporidia in the genus Encephalitozoon have been extensively studied for their minimalistic features, but they have seldom been used to investigate basic characteristics of the biology of these organisms, such as their ploidy or their mode of reproduction. In the present study, we aimed to tackle this issue by mapping Illumina sequence reads against the genomes of four strains of E. cuniculi. This approach, combined with more conventional molecular biology techniques, resulted in the identification of heterozygosity in all strains investigated, a typical signature of a diploid nuclear state. In sharp contrast with similar studies recently performed on a distant microsporidian lineage (Nematocida spp.), the level of heterozygosity that we identified across the E. cuniculi genomes was found to be extremely low. This reductive intraindividual genetic variation could result from the long-term propagation of these strains under laboratory conditions, but we propose that it could also reflect an intrinsic capacity of these vertebrate pathogens to self-reproduce.
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