ArticleInternational urogynecology journal2013
Changes in nerve growth factor level and symptom severity following antibiotic treatment for refractory overactive bladder.
Article in International urogynecology journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- The use of urinary biomarkers in the diagnosis of overactive bladder in female patients. A systematic review and meta-analysis.International urogynecology journal · 2021Pooled it
- Urinary cytokines in women with refractory detrusor overactivity: A longitudinal study of rotating antibiotic versus placebo treatment.PloS one · 2021Trial
- Antibiotic therapy for treating overactive bladder is not supported by clinical evidence.Nature reviews. Urology · 2025Review
- The Potential Role of Urinary Microbiome in Benign Prostate Hyperplasia/Lower Urinary Tract Symptoms.Diagnostics (Basel, Switzerland) · 2022Review
- Urinary Tract Infection in Overactive Bladder: An Update on Pathophysiological Mechanisms.Frontiers in physiology · 2022Review
- A blinded observational cohort study of the microbiological ecology associated with pyuria and overactive bladder symptoms.International urogynecology journal · 2018Observational
- Mechanisms Underlying Overactive Bladder and Interstitial Cystitis/Painful Bladder Syndrome.Frontiers in neuroscience · 2018Review
- Efficacy of Transcutaneous Electrical Nerve Stimulation in the Treatment of Overactive Bladder.Journal of clinical and diagnostic research : JCDR · 2016Article
- Urinary nerve growth factor and a variable solifenacin dosage in patients with an overactive bladder.International urogynecology journal · 2016Article
- Urinary nerve growth factor in patients with detrusor overactivity.Irish journal of medical science · 2015Article
- Refractory overactive bladder: a common problem?International urogynecology journal · 2015Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introduction and hypothesisOveractive bladder (OAB) has a multifactorial aetiology, and for some women symptoms may be associated with chronic urothelial inflammation secondary to bacterial colonisation. One marker of such inflammation may be urinary nerve growth factor (NGF). We hypothesised that for women with OAB and urothelial inflammation, urinary NGF would be reduced following antibiotic therapy.
methodsWomen with overactive bladder and urodynamic diagnosis of detrusor overactivity who were refractory to anticholinergics, and had histological evidence of urothelial inflammation were treated with a 6-week course of rotating antibiotics. Urinary NGF was measured by ELISA before and after treatment. Three-day bladder diaries, the Patients' Perception of Intensity of Urgency Scale, the King's Health Questionnaire and the Patients' Perception of Bladder Condition questionnaire were used to assess subjective and objective outcomes of therapy.
resultsThirty-nine women with refractory DO were recruited. The NGF levels decreased significantly after antibiotic therapy (Wilcoxon signed rank test; p = 0.015). There were significant improvements in daytime frequency, nocturia and urgency (p < 0.05), and 74 % of women reported improvement in perception of their bladder condition.
conclusionsUrinary NGF is responsive to antibiotic therapy. Women with refractory overactive bladder and elevated NGF may benefit from antibiotic treatment.
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