Evidence map›Paper›PMID 23376845›Full record

ArticleOncogene2013

Thyroid hormone suppresses cell proliferation through endoglin-mediated promotion of p21 stability.

Y-H Lin, Y-H Huang, M-H Wu, S-M Wu, H-C Chi, C-J Liao, C-Y Chen, Y-H Tseng, C-Y Tsai, M-M Tsai and 1 more

Open access · bronzeAbstract read
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In one paragraph

Article in Oncogene, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Y-H LinDepartment of Biochemistry, College of Medicine, Chang-Gung University, Taoyuan, Taiwan, Republic of China.
Y-H Huang
M-H Wu
S-M Wu
H-C Chi
C-J Liao
C-Y Chen
Y-H Tseng
C-Y Tsai
M-M Tsai
K-H Lin
Chang Gung University · TWChang Gung Memorial Hospital · TWChang Gung University of Science and Technology · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypothyroidism has been associated with significantly elevated risk for hepatocellular carcinoma (HCC), although the precise underlying mechanisms remain unknown at present. Thyroid hormone (T3) and its receptor (TR) are involved in metabolism and growth. Endoglin is a T3/TR candidate target gene identified from our previous studies. Here, we demonstrated that T3 positively regulates endoglin mRNA and protein levels, both in vitro and in vivo. The thyroid hormone response elements of endoglin were identified at positions -2114/-2004 and -2032/-1973 of the promoter region using the electrophoretic mobility shift assay and chromatin immunoprecipitation assay. Endoglin was downregulated in the subgroups of HCC patients and significantly associated with histology grade (negative association, P=0.001), and this expression level was significantly associated with TRα1 in these HCC patients. Our results clearly indicate that p21 is involved in T3-mediated suppression of cell proliferation. Knock down of endoglin expression in HCC cells facilitated p21 polyubiquitination and promoted cell proliferation in the presence of T3. The data collectively suggest that T3/TR signaling suppresses cell proliferation by upregulating endoglin, in turn, affecting p21 stability. The results indicate that endoglin has a suppressor role to inhibit cell proliferation in HCC cell lines.

Indexed as

Cell ProliferationAntigens, CDCarcinoma, HepatocellularCell Line, TumorChromatin ImmunoprecipitationCyclin-Dependent Kinase Inhibitor p21Electrophoretic Mobility Shift AssayEndoglinGene Expression Regulation, NeoplasticHumansImmunoblottingImmunohistochemistryLiver NeoplasmsProtein StabilityReceptors, Cell SurfaceReceptors, Thyroid HormoneAntigens, CDCyclin-Dependent Kinase Inhibitor p21EndoglinENG protein, humanReceptors, Cell SurfaceReceptors, Thyroid HormoneTriiodothyronine

Identifiers

PMID23376845
OpenAlexW2053928010

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.