ArticleAnadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology2013
Use of cardiac CT angiography imaging in an epidemiology study - the Methodology of the Multicenter AIDS Cohort Study cardiovascular disease substudy.
Article in Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 38 citations in OpenAlex.
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- Epicardial and intra-thoracic adipose tissue and cardiovascular calcifications in type 1 diabetes (T1D) in epidemiology of diabetes Interventions and Complications (EDIC): A pilot study.American journal of preventive cardiology · 2024Article
- Suboptimal HIV suppression is associated with progression of coronary artery stenosis: The Multicenter AIDS Cohort Study (MACS) longitudinal coronary CT angiography study.Atherosclerosis · 2022Article
- Subclinical cardiovascular disease in HIV controller and long-term nonprogressor populations.HIV medicine · 2020Article
- Association of High-Sensitivity Troponin with Cardiac CT Angiography Evidence of Myocardial and Coronary Disease in a Primary Prevention Cohort of Men: Results from MACS.The journal of applied laboratory medicine · 2019Article
- Associations between subcutaneous fat density and systemic inflammation differ by HIV serostatus and are independent of fat quantity.European journal of endocrinology · 2019Article
- HIV Infection Is Associated with Greater Left Ventricular Mass in the Multicenter AIDS Cohort Study.AIDS research and human retroviruses · 2019Article
- Associations between lipids and subclinical coronary atherosclerosis.AIDS (London, England) · 2019Observational
- GlycA, a novel inflammatory marker, is associated with subclinical coronary disease.AIDS (London, England) · 2019Article
- Article
- Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study: rationale and design.Coronary artery disease · 2018Article
- Frailty and subclinical coronary atherosclerosis: The Multicenter AIDS Cohort Study (MACS).Atherosclerosis · 2017Article
- Visceral fat is associated with brain structure independent of human immunodeficiency virus infection status.Journal of neurovirology · 2017Article
- Glomerular filtration rate and proteinuria associations with coronary artery calcium among HIV-infected and HIV-uninfected men in the Multicenter AIDS Cohort Study.Coronary artery disease · 2017Article
- Associations between antiretroviral use and subclinical coronary atherosclerosis.AIDS (London, England) · 2016Article
- Cardiovascular disease risk scores' relationship to subclinical cardiovascular disease among HIV-infected and HIV-uninfected men.AIDS (London, England) · 2016Article
- Inflammatory Markers Associated With Subclinical Coronary Artery Disease: The Multicenter AIDS Cohort Study.Journal of the American Heart Association · 2016Article
- Brief Report: Intestinal Microbiota-Produced Trimethylamine-N-Oxide and Its Association With Coronary Stenosis and HIV Serostatus.Journal of acquired immune deficiency syndromes (1999) · 2016Article
- Anatomic Fat Depots and Coronary Plaque Among Human Immunodeficiency Virus-Infected and Uninfected Men in the Multicenter AIDS Cohort Study.Open forum infectious diseases · 2016Article
- Comparison of Insulin Resistance to Coronary Atherosclerosis in Human Immunodeficiency Virus Infected and Uninfected Men (from the Multicenter AIDS Cohort Study).The American journal of cardiology · 2016Observational
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe methodology for use of cardiac CT angiography (CTA) in low risk populations is not well defined. In order to present a reference for future studies, we present CTA methodology that is being used in an epidemiology study- the Multicenter AIDS Cohort Study (MACS).
methodsThe Multicenter AIDS Cohort Study (MACS) is an on-going multicenter prospective, observational cohort study. The MACS Cardiovascular Disease substudy plans to enroll 800 men (n= 575 HIV seropositive and n=225 HIV seronegative) age 40-70 years for coronary atherosclerosis imaging using cardiac CTA. The protocol includes heart rate (HR) optimization with beta- blockers; use of proper field of view; scan length limitation; prospective ECG-gating using the lowest beam voltage possible. All scans are evaluated for presence, extent, and composition of coronary atherosclerosis, left atrial volumes, left ventricular volume and mass and non-coronary cardiac pathology.
resultsThe first 498 participants had an average radiation dose of 2.5±1.6 milliSieverts (mSv) for the cardiac CTA study. Overall quality of scans was fair to excellent in 98.6% of studies. There were three significant adverse events-two allergic reactions to contrast and one subcutaneous contrast extravasation.
conclusionCardiac CTA was safe and afforded a low effective radiation exposure to these asymptomatic research participants and provides valuable cardiovascular endpoints for scientific analysis. The cardiac CTA methodology described here may serve as a reference for use in future epidemiology studies aiming to assess coronary atherosclerosis and cardiac anatomy in low risk populations while minimizing radiation exposure.
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