Evidence map›Paper›PMID 23376627›Full record

ReviewExperimental gerontology2013

Benefits of short-term dietary restriction in mammals.

Lauren T Robertson, James R Mitchell

Registry-linked trialAbstract readReview
In one paragraph

Review in Experimental gerontology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05457881 (Short-Term Endogenous Hydrogen Sulfide Upregulation For Vein Graft Disease), which is not on this map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05457881 nawithdrawnnot on this mapstarted 2024, after this paper: background citation

Short-Term Endogenous Hydrogen Sulfide Upregulation For Vein Graft Disease

TypeinterventionalSponsorBrigham and Women's HospitalRan2024 to 2029Enrolled0ConditionsVascular Diseases, SurgeryArmsScandi-Shake
3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 110 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
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  5. Article
  6. Article
  7. Liraglutide pretreatment attenuates sepsis-induced acute lung injury.American journal of physiology. Lung cellular and molecular physiology · 2023
    Article
  8. Article
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  12. Article
  13. Article
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  15. Article
  16. Review
  17. Can intermittent fasting be helpful for knee osteoarthritis?Journal of clinical orthopaedics and trauma · 2021
    Review
  18. Long-Term Shaping of Corticostriatal Synaptic Activity by Acute Fasting.International journal of molecular sciences · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Lauren T RobertsonDepartment of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA, United States.
James R Mitchell
Harvard University · US

Funding

Interdisciplinary Training in Genes and the EnvironmentT32ES016645 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI LEE, CHIH-HAO · 2008 to 2018
$4.0M
Mechanisms of dietary control of the transsulfuration pathway and increased endogenous hydrogen sulfide productionR01DK090629 · NIDDK · HARVARD SCHOOL OF PUBLIC HEALTH · PI MITCHELL, SARAH JAYNE · 2011 to 2019
$3.0M
Protection against renal ischemic injury by short term dietary restrictionR01AG036712 · NIA · HARVARD SCHOOL OF PUBLIC HEALTH · PI MITCHELL, JAMES R. · 2010 to 2014
$1.6M
Dietary restriction promotes vascular health through hydrogen sulfide-mediated angiogenesisR56AG036712 · NIA · HARVARD SCHOOL OF PUBLIC HEALTH · PI MITCHELL, JAMES R. · 2017 to 2017
$398k
NIA NIH HHS AG036712NIA NIH HHS R01 AG036712NIA NIH HHS R56 AG036712NIDDK NIH HHS DK090629NIDDK NIH HHS R01 DK090629NIEHS NIH HHS T32 ES016645
6 · The paper itself

Abstract

Dietary or calorie restriction (DR, CR), defined as reduced food intake without malnutrition, imparts many benefits in model organisms. Extended longevity is the most popularized benefit but the least clinically relevant due to the requirement for long-term food restriction. DR also promotes stress resistance and metabolic fitness. Emerging data in experimental models and in humans indicate that these benefits occur rapidly upon initiation of DR, suggesting potential clinical relevance. Here we review data on the ability of short-term DR to induce beneficial effects on clinically relevant endpoints including surgical stress, inflammation, chemotherapy and insulin resistance. The encouraging results obtained in these preclinical and clinical studies, and the general lack of mechanistic understanding, both strongly suggest the need for further research in this emerging area.

Indexed as

Caloric RestrictionAnimal HusbandryAnimalsAntineoplastic AgentsDisease Models, AnimalEnergy MetabolismFastingHumansImmunity, InnateInflammationIschemic PostconditioningIschemic PreconditioningLongevityMammalsNeoplasmsPoultryAntineoplastic AgentsChemotherapyDietary restrictionInflammationIschemia reperfusion injuryStress resistance

Identifiers

PMID23376627
PMCPMC3745522
OpenAlexW1987107881

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.