Evidence map›Paper›PMID 23376497›Full record

ArticleJournal of neuroscience methods2013

Functional connectivity fMRI in mouse brain at 7T using isoflurane.

David N Guilfoyle, Scott V Gerum, Jamie L Sanchez, Andrea Balla, Henry Sershen, Daniel C Javitt, Matthew J Hoptman

Abstract read
In one paragraph

Article in Journal of neuroscience methods, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 54 citations in OpenAlex.

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  17. Mesoscale Mapping of Mouse Cortex Reveals Frequency-Dependent Cycling between Distinct Macroscale Functional Modules.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017
    Article
  18. Review
  19. Angiotensin II, hypertension and angiotensin II receptor antagonism: Roles in the behavioural and brain pathology of a mouse model of Alzheimer's disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

David N GuilfoyleCenter for Advanced Brain Imaging, Nathan Kline Institute, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA. dguilfoyle@nki.rfmh.org
Scott V Gerum
Jamie L Sanchez
Andrea Balla
Henry Sershen
Daniel C Javitt
Matthew J Hoptman
Nathan Kline Institute for Psychiatric Research · USAlbert Einstein College of Medicine · USColumbia University · USNew York University · US

Funding

The Conte Center for Schizophrenia ResearchP50MH086385 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JAVITT, DANIEL C. · 2009 to 2013
$10.7M
PHENCYCLIDINE ABUSE &PSYCHOSIS--BIOMEDICAL MECHANISMSR01DA003383 · NIDA · YESHIVA UNIVERSITY · PI JAVITT, DANIEL C. · 1985 to 2010
$3.2M
7.0 Tesla Upgrade for Basic Psychiatric ResearchS10RR023534 · NCRR · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI BRANCH, CRAIG A · 2007 to 2007
$500k
Functional connectivity and DTI in schizophreniaR21MH084031 · NIMH · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI HOPTMAN, MATTHEW J · 2009 to 2010
$428k
NCRR NIH HHS 1S10RR023534-01NCRR NIH HHS S10 RR023534NIDA NIH HHS R01 DA003383NIDA NIH HHS R01 DA03383NIMH NIH HHS P50 MH086385NIMH NIH HHS R21 MH084031
6 · The paper itself

Abstract

Although many resting state fMRI human studies have been published, the number of such rodent studies is considerably less. The reason for this is the severe technical challenge of high magnetic field small rodent imaging. Local magnetic field susceptibility changes at air tissue boundaries cause image distortion and signal losses. The current study reports measures of functional connectivity in mice using only isoflurane for the anesthetic. Because all anesthetic agents will alter cerebral blood flow and cerebral metabolism, the impact these changes have on neuronal connectivity has yet to be fully understood, however this work reports for the first time that reliable functional connectivity measures in mouse brain can be obtained with isoflurane.

Indexed as

Anesthetics, InhalationAnimalsBrainBrain MappingCerebrovascular CirculationFunctional NeuroimagingIsofluraneMagnetic Resonance ImagingMaleMiceMice, Inbred C57BLNerve NetNeuronsAnesthetics, InhalationIsoflurane

Identifiers

PMID23376497
PMCPMC3644382
OpenAlexW2057251472

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.