Evidence map›Paper›PMID 23375977›Full record

ReviewVaccine2013

Chlamydia trachomatis control requires a vaccine.

Robert C Brunham, Rino Rappuoli

Abstract readReview
In one paragraph

Review in Vaccine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

  1. Trial
  2. CXCR6 marks polyfunctional effector CD4 T cells required for anti-bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Viral Vector-BasedVaccines · 2024
    Article
  6. Addressing Challenges inMedicina (Kaunas, Lithuania) · 2024
    Review
  7. Article
  8. Article
  9. Article
  10. Association between serumFrontiers in public health · 2023
    Article
  11. Therapeutic Options forAntibiotics (Basel, Switzerland) · 2022
    Review
  12. Article
  13. Overexpression of the Bam Complex Improves the Production ofInternational journal of molecular sciences · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Protection of outbred mice against a vaginal challenge by aHuman vaccines & immunotherapeutics · 2020
    Article
  18. Article
  19. Article
  20. Does infection withSexually transmitted infections · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Robert C BrunhamUniversity of British Columbia and the British Columbia Centre for Disease Control, Vancouver, Canada. robert.brunham@bccdc.ca
Rino Rappuoli

Funding

Development of a Chlamydia T Cell Vaccine Based on Dendritic Cell ImmunoprotemicsR01AI076483 · NIAID · UNIVERSITY OF BRITISH COLUMBIA · PI BRUNHAM, ROBERT CONRAD, FOSTER, LEONARD J · 2008 to 2012
$1.1M
NIAID NIH HHS R01 AI076483
6 · The paper itself

Abstract

As the most common reported communicable disease in North America and Europe, Chlamydia trachomatis is the focus of concerted public health control efforts based on screening and treatment. Unexpectedly control efforts are accompanied by rising reinfection rates attributed in part to arresting the development of herd immunity. Shortening the duration of infection through the testing and treatment program is the root cause behind the arrested immunity hypothesis and because of this a vaccine will be essential to control efforts. Advances in Chlamydia vaccinomics have revealed the C. trachomatis antigens that can be used to constitute a subunit vaccine and a vaccine solution appears to be scientifically achievable. We propose that an accelerated C. trachomatis vaccine effort requires coordinated partnership among academic, public health and private sector players together with a commitment to C. trachomatis vaccine control as a global public health priority.

Indexed as

Bacterial VaccinesChlamydia trachomatisHealth PolicyAnimalsChlamydia InfectionsGlobal HealthHumansImmunity, HerdPublic HealthVaccines, SubunitBacterial VaccinesVaccines, Subunit

Identifiers

PMID23375977
PMCPMC4148049

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.