Evidence map›Paper›PMID 23375955›Full record

ReviewTrends in cell biology2013

Quality control mechanisms during ribosome maturation.

Katrin Karbstein

Abstract readReview
In one paragraph

Review in Trends in cell biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 103 citations in OpenAlex.

  1. RiboScreenBiomedicines · 2026
    Review
  2. Nucleolar Dynamics During Oogenesis.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Neuronal processes contain the essential components for the late steps of ribosome biogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Mitoribosomal small subunit maturation involves formation of initiation-like complexes.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Local translation in nuclear condensate amyloid bodies.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  18. Article
  19. Article
  20. Article

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Katrin KarbsteinDepartment of Cancer Biology, The Scripps Research Institute, 130 Scripps Way #2C2, Jupiter, FL 33458, USA. kkarbst@scripps.edu
Scripps Research Institute · US

Funding

Quality Control in Ribosome Assembly - the Function of Regulatory ProteinsR01GM086451 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARBSTEIN, KATRIN · 2009 to 2019
$4.8M
NIGMS NIH HHS R01 GM086451NIGMS NIH HHS R01GM086451
6 · The paper itself

Abstract

Protein synthesis on ribosomes is carefully quality-controlled to ensure the faithful transmission of genetic information from mRNA to protein. Many of these mechanisms rely on communication between distant sites on the ribosomes, and thus on the integrity of the ribosome structure. Furthermore, haploinsufficiency of ribosomal proteins, which increases the chances of forming incompletely assembled ribosomes, can predispose to cancer. Finally, release of inactive ribosomes into the translating pool will lead to their degradation together with the degradation of the bound mRNA. Together, these findings suggest that quality control mechanisms must be in place to survey nascent ribosomes and ensure their functionality. This review gives an account of these mechanisms as currently known.

Indexed as

Anemia, Diamond-BlackfanAnemia, MacrocyticBinding SitesChromosome DeletionChromosomes, Human, Pair 5HumansLigandsPeptide Chain Initiation, TranslationalProtein BiosynthesisQuality ControlRibosomal ProteinsRibosomesRibosome Subunits, Large, EukaryoticRibosome Subunits, Small, EukaryoticRNA, MessengerRNA, RibosomalLigandsRibosomal ProteinsRNA, MessengerRNA, Ribosomal

Identifiers

PMID23375955
PMCPMC3640646
OpenAlexW1992894587

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.