ArticleCurrent biology : CB2013
Architectural insights into a ciliary partition.
Article in Current biology : CB, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- Homology search confirms widespread presence of BBSome proteins in Hexapoda with implications for potential non-ciliary BBS protein functions in honey bees.Scientific reports · 2025Article
- Composition, organization and mechanisms of the transition zone, a gate for the cilium.EMBO reports · 2022Review
- Structure, function and druggability of the African trypanosome flagellum.Journal of cellular physiology · 2022Review
- Evolutionary History of GLIS Genes Illuminates Their Roles in Cell Reprograming and Ciliogenesis.Molecular biology and evolution · 2020Article
- An orphan kinesin controls trypanosome morphology transitions by targeting FLAM3 to the flagellum.PLoS pathogens · 2018Article
- Mechanisms of ciliary targeting: entering importins and Rabs.Cellular and molecular life sciences : CMLS · 2018Review
- Kinesin-2 motors adapt their stepping behavior for processive transport on axonemes and microtubules.EMBO reports · 2017Article
- Intraflagellar transport: mechanisms of motor action, cooperation, and cargo delivery.The FEBS journal · 2017Review
- Lineage-specific proteins essential for endocytosis in trypanosomes.Journal of cell science · 2017Article
- Intraflagellar Transport and Ciliary Dynamics.Cold Spring Harbor perspectives in biology · 2017Review
- Cilium transition zone proteome reveals compartmentalization and differential dynamics of ciliopathy complexes.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Mechanism of ciliary disassembly.Cellular and molecular life sciences : CMLS · 2016Review
- Gated entry into the ciliary compartment.Cellular and molecular life sciences : CMLS · 2016Review
- The essential roles of transition fibers in the context of cilia.Current opinion in cell biology · 2015Review
- CEP290 alleles in mice disrupt tissue-specific cilia biogenesis and recapitulate features of syndromic ciliopathies.Human molecular genetics · 2015Article
- Paramecium tetraurelia basal body structure.Cilia · 2015Review
- An inside-out origin for the eukaryotic cell.BMC biology · 2014Article
- An assay for clogging the ciliary pore complex distinguishes mechanisms of cytosolic and membrane protein entry.Current biology : CB · 2014Article
- Ciliopathies: the trafficking connection.Traffic (Copenhagen, Denmark) · 2014Review
- The SUN protein Mps3 controls Ndc1 distribution and function on the nuclear membrane.The Journal of cell biology · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Ciliary compartmentalization plays pivotal roles in ciliogenesis and in various signaling pathways. Here we describe a structure at the ciliary base that appears to have all the features required for compartmentalization and which we thus call the "ciliary partitioning system" (CPS). This complex consists of the terminal plate, which serves as a cytosolic "ciliary pore complex" (CPC), and a membrane region well suited to serve as a diffusion barrier. The CPC is a plate-shaped structure containing nine pores through which the microtubule doublets of the basal body pass. Each pore expands from the doublet B-tubule into an opening well suited for the passage of intraflagellar transport particles. The membrane diffusion barrier encompasses an extended region of detergent-resistant periciliary membrane (ciliary pocket) and a ring complex that connects the CPC to the membrane. Proteomics analysis shows involvement of the ciliary pocket in vesicle trafficking, suggesting that this region plays an active role in membrane transport. The CPC and the ring together form a complete partition defining the ciliary boundary.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.