ArticleEpilepsy research2013
A neurodevelopmental basis for BECTS: evidence from structural MRI.
Article in Epilepsy research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neurodevelopmental origins of self-limiting rolandic epilepsy: Systematic review of MR imaging studies.Epilepsia open · 2021Pooled it
- Altered white matter structural network in self-limited epilepsy with centrotemporal spikes.Quantitative imaging in medicine and surgery · 2026Article
- Linking Cortical Morphometry in Self-Limited Epilepsy With Centrotemporal Spikes to Cognition, Function, and Molecular Architecture.CNS neuroscience & therapeutics · 2026Article
- Multidimensional dataset for cognitive assessment, sMRI, and rsfMRI in common benign epileptic children.Scientific data · 2025Article
- Predicting progression from SeLECTS with SWAS to EE-SWAS: risk factor identification and model development.Frontiers in human neuroscience · 2025Article
- Combined diffusion tensor imaging and quantitative susceptibility mapping to characterize normal-appearing white matter in self-limited epilepsy with centrotemporal spikes.Neuroradiology · 2024Article
- Brain structural changes and molecular analyses in children with benign epilepsy with centrotemporal spikes.Pediatric research · 2024Article
- Perisylvian and Hippocampal Anomalies in Individuals With PathogenicNeurology. Genetics · 2024Article
- Structural and functional changes in drug-naïve benign childhood epilepsy with centrotemporal spikes and their associated gene expression profiles.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Activation Map Reveals Language Impairment in Children with Benign Epilepsy with Centrotemporal Spikes (BECTS).Neuropsychiatric disease and treatment · 2023Article
- Brain magnetic resonance imaging findings and brain volumetric differences in a large series of benign rolandic epilepsy.The neuroradiology journal · 2022Article
- Influence of epileptogenic region on brain structural changes in Rolandic epilepsy.Brain imaging and behavior · 2022Article
- Delayed brain development of Rolandic epilepsy profiled by deep learning-based neuroanatomic imaging.European radiology · 2021Article
- Impairment of eye emotion discrimination in benign childhood epilepsy with centrotemporal spikes: A neuropsychological study.Brain and behavior · 2021Article
- Altered Sleep-Related Consolidation and Neurocognitive Comorbidity in CECTS.Frontiers in human neuroscience · 2021Review
- The relationship between epilepsy and cognitive function in benign childhood epilepsy with centrotemporal spikes.Brain and behavior · 2020Article
- Cortical and subcortical volume differences between Benign Epilepsy with Centrotemporal Spikes and Childhood Absence Epilepsy.Epilepsy research · 2020Article
- Surface-based morphometry study of the brain in benign childhood epilepsy with centrotemporal spikes.Annals of translational medicine · 2020Article
- Neural correlates of verbal working memory in children with epilepsy with centro-temporal spikes.NeuroImage. Clinical · 2020Article
- Frequency-Dependent Interictal Neuromagnetic Activities in Children With Benign Epilepsy With Centrotemporal Spikes: A Magnetoencephalography (MEG) Study.Frontiers in human neuroscience · 2020Article
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5 authors.
Funding
Abstract
purposeBECTS (benign epilepsy with centro-temporal spikes) is one of the most common childhood-onset epilepsy syndromes. We investigated quantitative evidence for brain morphological variation associated with BECTS to provide insights into the neuroanatomical basis of this disorder.
methodsThree independent BECTS groups were imaged at different stages: (a) near onset (n=16, mean age 9.3±1.6 years), (b) ~9 years after onset (n=9, mean age 15.8±2.3 years), and (c) ~15 years after onset (n=10, mean age 22.7±2.7 years). Age-matched controls were imaged with each group. Whole brain T1-weighted MRI was acquired. Voxel-based morphometry (groups a-c) and cortical thickness analyses (groups b and c) were undertaken within each group and for the groups combined. The relationship between cortical morphology and age was investigated. KEY
findingsThe voxel-based morphometry analysis indicated increased bilateral grey matter volume in the superior frontal gyrus, insula and right inferior frontal gyrus regions in BECTS. The magnitude of the increase lessened with age of the cases. Cortical thickness analysis revealed thicker cortex in BECTS along middle and inferior frontal gyri bilaterally, left insula and bilateral supramarginal gyrus in the 9-year-after-onset group, that normalised with age. The rate of cortical thickness changes with age were greater in BECTS cases than in controls. SIGNIFICANCE: Increased cortical gray matter associated with BECTS was found. The decreasing magnitude of the effect with increasing age parallels the natural history of the disorder. The areas affected are consistent with neurocognitive dysfunction in BECTS.
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