ArticleJournal of pediatric urology2013
Prevalence and spot urine risk factors for renal stones in children taking topiramate.
Article in Journal of pediatric urology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- The acid-base balance homeostasis reflected by urine pH in children with infantile epileptic spasm syndrome may be associated with response to adrenocorticotropic hormone treatment: a retrospective cohort study.Translational pediatrics · 2025Article
- Observational
- Refractory uric acid nephrolithiasis dissolution using phentermine/topiramate: A case report.Urology case reports · 2024Article
- A rise in saliva and urine pH in children withFrontiers in neurology · 2022Article
- Educational review: role of the pediatric nephrologists in the work-up and management of kidney stones.Pediatric nephrology (Berlin, Germany) · 2020Review
- Drug-Induced Urolithiasis in Pediatric Patients.Paediatric drugs · 2019Review
- Incomplete Distal Renal Tubular Acidosis and Kidney Stones.Advances in chronic kidney disease · 2018Review
- Nephrolithiasis and Nephrocalcinosis From Topiramate Therapy in Children With Epilepsy.Kidney international reports · 2018Article
- Drug-Induced Kidney Stones and Crystalline Nephropathy: Pathophysiology, Prevention and Treatment.Drugs · 2018Review
- Endemic bladder calculi in children.Pediatric nephrology (Berlin, Germany) · 2017Review
- Use of Ultrasound in Pediatric Renal Stone Diagnosis and Surgery.Current urology reports · 2017Review
- Trends in pediatric urolithiasis: patient characteristics, associated diagnoses, and financial burden.Pediatric nephrology (Berlin, Germany) · 2015Article
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7 authors at 4 institutions in 1 country.
Funding
Abstract
introductionTopiramate (TPM), an anti-epileptic drug with >4 million users, increases renal stones in adults. We screened outpatient TPM-treated children without history of stones to estimate the prevalence of renal stones and to characterize urine stone-risk profiles.
methodsChildren taking TPM ≥1 month underwent an interview, renal ultrasound, and spot urine testing in this prospective study. Normal spot urine values were defined as: calcium/creatinine ratio ≤0.20 mg/mg (>12 months) or ≤0.60 mg/mg (≤12 months), citrate/creatinine ratio >0.50 mg/mg, and pH ≤ 6.7.
resultsOf 41 patients with average age of 9.2 years (range 0.5-18.7), mean TPM dose of 8.0 mg/kg/day (range 1.4-23.6), and mean treatment duration of 27 months (range 1-112), two (4.9%) had renal stones. The majority of children taking TPM had lithogenic abnormalities on spot urine testing, including 21 (51%) with hypercalciuria, 38 (93%) with hypocitraturia, and 28 (68%) with pH ≥ 6.7. Hypercalciuria and hypocitraturia were independent of TPM dose and duration; urine pH increased with dose. 24-h urine parameters improved in 1 stone-former once TPM was weaned.
conclusionsAsymptomatic stones were found in 2/41 (4.8%) children taking TPM. Risk factors for stones were present in the spot urine of most children, including hypocitraturia (93%) and hypercalciuria (51%), independent of TPM dose and duration. High urine pH, found in 68%, correlated with TPM dose. Pediatric specialists should be aware of increased risks for stones, hypercalciuria, hypocitraturia, and alkaline urine in children taking TPM.
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