SynthesisFertility and sterility2013
Evaluating reported candidate gene associations with polycystic ovary syndrome.
Synthesis in Fertility and sterility, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00166569 (The Genetics of Polycystic Ovarian Syndrome), which is not on this map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Genetics of Polycystic Ovarian Syndrome
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- A Comprehensive Overview of Common Polymorphic Variants in Genes Related to Polycystic Ovary Syndrome.Reproductive sciences (Thousand Oaks, Calif.) · 2021Pooled it
- Effects of ADIPOQ polymorphisms on PCOS risk: a meta-analysis.Reproductive biology and endocrinology : RB&E · 2018Pooled it
- Analysis of the association between cytokine expression in the endometrial microenvironment and insulin resistance in polycystic ovary syndrome.Endocrine · 2026Article
- POLYCYSTIC OVARY SYNDROME: ORIGINS AND IMPLICATIONS: Genetics of polycystic ovary syndrome (PCOS).Reproduction (Cambridge, England) · 2025Review
- Deconstructing a Syndrome: Genomic Insights Into PCOS Causal Mechanisms and Classification.Endocrine reviews · 2022Article
- Relationship between the characteristic traits of polycystic ovary syndrome and susceptibility genes.Scientific reports · 2020Article
- Hyperandrogenism in POMCa-deficient zebrafish enhances somatic growth without increasing adiposity.Journal of molecular cell biology · 2020Article
- Association between sex hormone binding globulin gene polymorphism and type 2 diabetes mellitus.International journal of clinical and experimental pathology · 2019Article
- Genetics of polycystic ovary syndrome.Seminars in reproductive medicine · 2014Review
- Polycystic ovary syndrome: current status and future perspective.Frontiers in bioscience (Elite edition) · 2014 · on this mapReview
- Ontogeny of polycystic ovary syndrome and insulin resistance in utero and early childhood.Fertility and sterility · 2013Review
- Whole Genome Sequencing instead of Whole Exome Sequencing is required to identify the Genetic Causes of Polycystic Ovary Syndrome in Pakistani families.Pakistan journal of medical sciencesArticle
- Association Between Single Nucleotide Polymorphisms (rs1484215 and rs6495096) in CYP11A1 Gene in Iranian Women with Polycystic Ovary Syndrome.Journal of reproduction & infertilityArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo replicate variants in candidate genes associated with polycystic ovary syndrome (PCOS) in a population of European women with PCOS and control subjects.
designCase-control association analysis and meta-analysis.
settingMajor academic hospital. PATIENT(S): Women of European ancestry with PCOS (n = 525) and controls (n = 472), aged 18-45 years. INTERVENTION(S): Variants previously associated with PCOS in candidate gene studies were genotyped (n = 39). Metabolic, reproductive, and anthropomorphic parameters were examined as a function of the candidate variants. All genetic association analyses were adjusted for age, body mass index, and ancestry and were reported after correction for multiple testing. MAIN OUTCOME MEASURE(S): Association of candidate gene variants with PCOS. RESULT(S): Three variants, rs3797179 (SRD5A1), rs12473543 (POMC), and rs1501299 (ADIPOQ), were nominally associated with PCOS. However, they did not remain significant after correction for multiple testing, and none of the variants replicated in a sufficiently powered meta-analysis. Variants in the FBN3 gene (rs17202517 and rs73503752) were associated with smaller waist circumferences, and variant rs727428 in the SHBG gene was associated with lower sex hormone-binding globulin levels. CONCLUSION(S): Previously identified variants in candidate genes do not seem to be associated with PCOS risk. CLINICAL TRIAL REGISTRATION NUMBER: NCT00166569.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.